Mechanism of altered synaptic strength due to experience: Relation to long-term potentiation
Mechanism of altered synaptic strength due to experience: Relation to long-term potentiation
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DOI：
10.1016/0006-8993(96)00707-x
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发表时间：
1996-10-14
期刊：
影响因子：
2.9
通讯作者：
Massicotte, G
中科院分区：
文献类型：
--
作者：
Foster, TC;Gagne, J;Massicotte, G
在暴露于环境富集的大鼠海马切片中可以观察到内侧穿通突触强度的增加。增强的突触强度的表达表现出类似于长时程增强（LTP）的特性，长时程增强是记忆存储的生理模型。相似之处包括在没有改变的成对脉冲比的情况下突触反应的强度增加和谷氨酸激动剂α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯的结合增加。此外，环境富集通过抑制LTP诱导刺激后突触强度的进一步增加与负责诱导LTP的机制相互作用。结果提供证据的经验介导的影响突触后机制调节内侧穿通路径突触强度。
An increase in medial perforant synaptic strength can be observed for hippocampal slices from rats exposed to environmental enrichment. The expression of enhanced synaptic strength exhibits properties similar to long-term potentiation (LTP), a physiological model of memory storage. Similarities include an increase in strength of the synaptic response in the absence of an altered paired-pulse ratio and an increase in the binding of the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate. Furthermore, environmental enrichment interacts with the mechanisms responsible for the induction of LTP by inhibiting further increases in synaptic strength following LTP-inducing stimulation. The results provide evidence for experience-mediated influences on postsynaptic mechanisms regulating medial perforant path synaptic strength.