Techniques for Molecular Imaging Probe Design
Techniques for Molecular Imaging Probe Design
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DOI：
10.2310/7290.2011.00003
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发表时间：
2011-11
影响因子：
2.8
通讯作者：
F. Reynolds;K. Kelly
中科院分区：
文献类型：
--
作者：
F. Reynolds;K. Kelly
分子成像使临床医生能够可视化疾病特异性分子，从而为患者的诊断和治疗提供相关信息。随着基因组学和蛋白质组学以及疾病病理的潜在机制的进步，已确定的靶标数量大大超过了已开发的分子成像探针的数量。化学、蛋白质组学、物理学、材料科学和生物学等多学科的共同努力弥补了这一差距，这些都对分子成像探针的发展至关重要。在这篇综述中，我们讨论了目标选择、筛选技术和探针优化，目的是开发临床相关的分子靶向显像剂。
Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology—all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.