ENDOGENOUS DIGOXIN-LIKE SUBSTANCE(S) ASSOCIATED WITH UNEVENTFUL AND HIGH-RISK PREGNANCIES
ENDOGENOUS DIGOXIN-LIKE SUBSTANCE(S) ASSOCIATED WITH UNEVENTFUL AND HIGH-RISK PREGNANCIES
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DOI：
10.1159/000457670
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发表时间：
1988-03-01
期刊：
影响因子：
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通讯作者：
MACLEOD, SM
中科院分区：
文献类型：
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作者：
KOREN, G;FARINE, D;MACLEOD, SM
我们使用地高辛常规放射免疫分析法评估了母婴对中内源性地高辛样物质（EDLS）的存在情况。研究对象在孕期或孕前均未接受过强心苷治疗。在正常妊娠中，脐带EDLS水平（平均值±标准误为0.31±0.02纳克/毫升）显著高于产前和产后母体水平（分别为0.14±0.02和0.17±0.02纳克/毫升）（p < 0.001）。这一观察结果与高危妊娠的情况相反。一般来说，高危组的EDLS水平显著高于正常妊娠（脐带为0.94±0.38纳克/毫升；产前为1.63±0.54纳克/毫升；产后为0.89±0.73纳克/毫升）。在高危组中，母体和脐带的EDLS浓度范围非常大。目前的研究表明，由于多种原因处于高危妊娠后，围产期EDLS测定值可能普遍较高，并可能影响“真正”地高辛的测定。因此，基于监测药物浓度的地高辛给药可能是徒劳的。
We assessed the existence of endogenous digoxin-like substance(s) (EDLS) in mother-neonate pairs using a routine radioimmunoassay for digoxin. None of those studied had been treated with cardiac glycosides during or before pregnancy. In uneventful pregnancies, cord EDLS levels (0.31 .+-. 0.02 ng/ml mean .+-. SEM) were significantly higher (p < 0.001) than both antepartum and postpartum maternal levels (0.14 .+-. 0.02 and 0.17 .+-. 0.02 ng/ml, respectively). This observation was in contrast with findings in high-risk pregnancies. In general, EDLS levels in the high-risk group were significantly higher than in normal pregnancies (cord 0.94 .+-. 0.38 ng/ml; antepartum 1.63 .+-. 0.54 ng/ml; postpartum 0.89 .+-. 0.73 ng/ml). In the high-risk group there was a remarkably wide range of maternal and cord EDLS concentrations. The present studies suggest that following pregnancies of high risk for a variety of reasons, EDLS determination may be commonly high in the perinatal period and may affect the determination of ''true'' digoxin. Consequently, digoxin dosing based on monitoring drug concentration may be futile.