Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids.
Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids.
复制标题
尽管存在皮质类固醇，但敏化的脾细胞仍会导致肺孢子虫肺炎大鼠产生有害的细胞因子级联反应和高炎症反应。
DOI：
10.1128/iai.72.2.757-765.2004
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发表时间：
2004
影响因子：
3.1
通讯作者：
Walzer,PeterD
中科院分区：
文献类型：
--
作者：
Thullen,TimothyD;Ashbaugh,AlanD;Daly,KieranR;Linke,MichaelJ;Steele,PaulE;Walzer,PeterD
尽管存在皮质类固醇，但对机会性肺部病原体肺孢子虫的免疫反应可能对宿主产生有益和有害的影响。我们假设这种有害的高炎症反应与细胞因子的过度产生有关。至少 107 个免疫脾细胞的过继移植减少了皮质类固醇诱导的肺囊肿病大鼠的囊肿数量。这些大鼠中约 18% 出现临床疾病，肺重量/体重 (LW/BW) 比率增加，肺部白细胞介素 1α (IL-1α)、IL-1β、IL-6、肿瘤坏死因子 α、IL-5、IL-10 和 γ 干扰素水平升高。在临床状况良好的大鼠或对照大鼠中没有观察到这种过度炎症反应。因此，在该模型中，皮质类固醇对细胞因子级联或宿主对肺孢子虫免疫反应的其他不利影响几乎没有影响。
The immune response to the opportunistic pulmonary pathogenPneumocystiscan have beneficial and harmful effects on the host despite the presence of corticosteroids. We hypothesized that this deleterious hyperinflammatory response is associated with exaggerated cytokine production. The adoptive transfer of at least 107immune splenocytes reduced the cyst count in rats with corticosteroid-induced pneumocystosis. About 18% of these rats developed clinical illness, an increased lung weight/body weight (LW/BW) ratio, and elevated levels of interleukin 1α (IL-1α), IL-1β, IL-6, tumor necrosis factor alpha, IL-5, IL-10, and gamma interferon in the lungs. This hyperinflammatory reaction was not observed in rats that remained clinically well or in control rats. Thus, in this model, corticosteroids have little effect on the cytokine cascade or other adverse effects of the host immune response toPneumocystis.