Frequency dependence of total respiratory resistance in early airway disease.
Frequency dependence of total respiratory resistance in early airway disease.
复制标题
早期气道疾病中总呼吸阻力的频率依赖性。
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Reichert Ww
中科院分区：
文献类型：
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作者：
Kjeldgaard Jm;Richard W. Hyde;Speers Dm;Reichert Ww
出现肺顺应性频率依赖性的患者，理论上也会出现肺阻力频率依赖性。我们研究了更简单的，非侵入性的测量频率依赖性的总呼吸阻力，以确定受试者的频率依赖性的依从性的能力。研究对象包括10名健康非吸烟者、14名无症状吸烟者和6名阻塞性气道疾病患者。总呼吸阻力的频率依赖性通过叠加振荡气流技术以每秒3至9次循环来确定，肺顺应性的频率依赖性通过每分钟10至80次呼吸的测量来确定。还测量了肺活量、气道阻力、闭合容积和闭合容量。频率依赖性肺顺应性与总呼吸阻力密切相关（P <0.001，r = 0.82），但关闭容积、关闭容量、肺功能测定和气道阻力不能用于识别肺顺应性频率依赖性异常的受试者。频率依赖性的总呼吸阻力和肺顺应性，总呼吸阻力在每秒3次，关闭容积减去呼气储备容积的测量能够区分吸烟者和不吸烟者，但肺功能测定，关闭容积，关闭容量，气道阻力不能。这些数据表明，在无症状吸烟者和阻塞性气道疾病的受试者，肺顺应性的频率依赖性可以预测从总呼吸阻力的频率依赖性的测量。这两种试验在检测无症状吸烟者气道中的不均匀时间常数方面似乎具有相同的灵敏度和选择性。
Patients who develop frequency dependence of lung compliance will theoretically have frequency dependence of pulmonary resistance. We investigated the ability of the simpler, noninvasive measurement of frequency dependence of total respiratory resistance to identify subjects with frequency dependence of compliance. Ten healthy nonsmokers, 14 asymptomatic smokers, and 6 patients with obstructive airway disease were studied. Frequency dependence of total respiratory resistance was determined by the superimposed oscillating airflow technique at 3 to 9 cycles per sec, and frequency dependence of lung compliance was determined by measurements at 10 to 80 breaths per min. Spirometry, airway resistance, closing volume, and closing capacity were also measured. Frequency dependence of lung compliance and total respiratory resistance were closely correlated (P less than 0.001, r = 0.82), but closing volume, closing capacity, spirometry, and airway resistance could not be used to identify subjects with abnormal frequency dependence of lung compliance. Measurements of frequency dependence of total respiratory resistance and lung compliance, total respiratory resistance at 3 cycles per sec, and closing volume minus expiratory reserve volume were able to distinguish significantly between the smokers and the nonsmokers, but spirometry, closing volume, closing capacity, and airway resistance could not. These data indicate that in asymptomatic smokers and subjects with obstructive airway disease, frequency dependence of lung compliance can be predicted from measurements of frequency dependence of total respiratory resistance. These two tests appear to have equivalent sensitivity and selectivity in detecting the uneven time constants in the airways of asymptomatic smokers.