A conditional inference framework for extending the transmission/disequilibrium test
A conditional inference framework for extending the transmission/disequilibrium test
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DOI：
10.1159/000022784
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发表时间：
1998-03-01
期刊：
影响因子：
1.8
通讯作者：
Lange, K
中科院分区：
文献类型：
--
作者：
Lazzeroni, LC;Lange, K
Terwilliger和Ott [Hered赫雷德1992;42：337-346]和Spielman等[Am J Genet 1993;52：506-516]的传递/不平衡检验（TDT）被广泛用于检测遗传影响的疾病与共显性标记基因座的等位基因之间的连锁和/或关联。TDT是专门设计的，以避免受影响人群样本的种族分层所产生的虚假人口关联。在本文中，我们描述了置换扩展的TDT共享这一优势。我们的条件推理框架允许扩展到多个等位基因，多个基因座，未受影响的兄弟姐妹，基因型，而不是等位基因协会。在多个基因座的情况下，条件视角为多个测试提供了直接的校正，其可以比标准Bonferroni校正更强大。
The transmission/disequilibrium test (TDT) of Terwilliger and Ott [Hum Hered 1992;42:337-346] and Spielman et al. [Am J Hum Genet 1993;52:506-516] is widely used to detect linkage and/or association between a genetically influenced disease and the alleles of a codominant marker locus. The TDT was specifically designed to avoid the spurious population associations produced by ethnic stratification of a sample of affected people. In this paper, we describe permutation extensions of the TDT that share this advantage. Our conditional inference framework permits extensions to multiple alleles, multiple loci, unaffected siblings, and genotypic rather than allelic associations. In the case of multiple loci, the conditional perspective provides a straightforward correction for multiple tests that can be substantially more powerful than the standard Bonferroni correction.