A cellular Trojan horse for delivery of therapeutic nanoparticles into tumors
A cellular Trojan horse for delivery of therapeutic nanoparticles into tumors
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DOI：
10.1021/nl072209h
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发表时间：
2007-12-01
期刊：
影响因子：
10.8
通讯作者：
Clare, Susan E.
中科院分区：
文献类型：
--
作者：
Choi, Mi-Ran;Stanton-Maxey, Katie J.;Clare, Susan E.
破坏肿瘤内几乎无法进行癌症治疗的缺氧区域，可以很好地防止恶性进展。肿瘤将单核细胞募集到这些区域中可以用于基于纳米颗粒的递送。含有治疗性纳米颗粒的单核细胞可以作为纳米颗粒转运到这些肿瘤区域的“特洛伊木马”。在这里，我们报告的几个关键步骤，这种治疗策略的示范：吞噬Au纳米壳，和单核细胞/巨噬细胞的光诱导细胞死亡的隔离和肿瘤球体内。
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.