Metabolism of14C-Leptophos and14C-4-Bromo-2, 5-dichlorophenol in rats: A multiple dosing study
Metabolism of14C-Leptophos and14C-4-Bromo-2, 5-dichlorophenol in rats: A multiple dosing study
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大鼠体内 14 C-细磷和 14 C-4-Bromo-2, 5-二氯苯酚的代谢：多次给药研究
DOI：
10.1007/bf01685574
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发表时间：
1976
影响因子：
2.7
通讯作者：
L. I. Diaz
中科院分区：
文献类型：
--
作者：
D. M. Whitacre;M. Badie;B. Schwemmer;L. I. Diaz
Leptophos r O-（4-bromo-2，5-dichlorophenyl）-O-methyl phenylthionophosphonate~是一种膦酸酯杀虫剂，在国际上用于控制棉花、某些蔬菜作物和烟草上的几种害虫。在美国，这种杀虫剂在临时许可下用于控制柑橘、某些水果和几种蔬菜作物上的害虫。膦酸酯杀虫剂的环境归宿已经得到很好的定义（MENN，1971年）。只有一篇论文报道了当施用给小型哺乳动物时，leptophos的命运（HOLMSTEAD等人，1973年）。他们报告说，小鼠单次口服14 C-leptophos后，很快就以极性代谢物的形式从尿液中排出。在另一项研究中，大鼠吸入香烟烟雾中的14 C-leptophos残留物在4天后几乎完全消除（> 90%）（ATALLAH等人，1975年）。
Leptophos rO-(4-bromo-2, 5-dichlorophenyl)-O-methyl phenylthionophosphonate~ is a phosphonate insecticide which is used internationally to control several pests on cotton, certain vegetable crops, and tobacco. The insecticide has been used under temporary permit in the US for control of pests on citrus, certain fruits, and several vegetable crops.The environmental fate of phosphonate insecticides has hot been well defined (MENN, 1971). Only one paper has been reported on the fate of leptophos when administered to small mammals (HOLMSTEAD et al., 1973). They reported that a single oral dose of 14C-leptophos given to mice was rapidly excreted in the urine, largely as polar metabolites. In a different study, 14C-leptophos residues inhaled by rats in cigarette smoke were almost totally eliminated (> 90%) after 4 days (ATALLAH et al., 1975).