LAMINAR DISTRIBUTION OF RECEPTIVE-FIELD PROPERTIES IN THE PRIMARY VISUAL-CORTEX OF THE MOUSE
LAMINAR DISTRIBUTION OF RECEPTIVE-FIELD PROPERTIES IN THE PRIMARY VISUAL-CORTEX OF THE MOUSE
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DOI：
10.1002/cne.901930114
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
PEARLMAN, AL
中科院分区：
文献类型：
--
作者：
MANGINI, NJ;PEARLMAN, AL
研究了小鼠初级视觉皮层（17区）单个神经元的感受野特性和感受野类型在皮层层间的分布，发现了3种基本的感受野类型。具有定向感受野的细胞可分为简单和复杂两类，它们存在于皮层的所有层，但在第2层和第3层发生的频率更高，在第4层发生的频率更低。具有非定向感受野的细胞有开、关或开-关中心；非定向感受野的亚类(2)是根据它们对静止和运动刺激的反应来划分的。一组具有非定向接受野的细胞对静止的闪烁刺激有强烈的持续放电反应，对大范围的运动刺激有良好的反应。第二组非定向细胞，称为运动选择性细胞，对静止刺激反应不佳或根本没有反应，而对运动刺激在有限的速度范围内反应最佳。一组独特的神经元，被称为大视野非定向（LFNO）细胞，几乎只在v层被发现。LFNO细胞在所有视野位置的接受野都比其他两大类细胞大；与其他班级相比，他们的自发活动率更高，对刺激速度的反应也更快。在这些方面，LFNO细胞类似于猫17区的V层细胞和猴17区的V层和VI层细胞，它们投射到上丘。将山葵过氧化物酶注射到上丘，确定小鼠皮质顶盖细胞位于V层，记录LFNO细胞的层。在初步的实验中，一些LFNO细胞投射到上丘，在实验中，上丘受到刺激，具有LFNO接受野的皮质细胞被反向激活。具有LFNO接受野的神经元构成了一类功能独特的神经元，其细胞体位于小鼠17区的单层(V)。
The receptive field properties of single neurons in the primary visual cortex (area 17) of the mouse and the distribution of receptive field types among the cortical laminae were studied and 3 basic receptive field types found. Cells with oriented receptive fields, many of which could be classified as simple or complex, were found in all layers of the cortex but occurred with greater frequency in layers II and III and less commonly in Layer IV. Cells with non-oriented receptive fields had on, off or on-off centers; they were found in all layers but were predominant in layer IV. Subclasses (2) of non-oriented receptive fields were characterized based on their responses to stationary and moving stimuli. One group of cells with non-oriented receptive fields responded vigorously with sustained firing to stationary flashing stimuli and responded well to moving stimuli over a wide range of stimulus velocities. A 2nd group of non-oriented cells, termed motion-selective, responded poorly or not at all to stationary stimuli and responded optimally to moving stimuli over a restricted range of velocities. A distinct group of neurons, termed large field, non-oriented (LFNO) cells, were found almost exclusively in layer V. LFNO cells had receptive fields that were larger than those of the other 2 major classes at all visual-field locations; they had higher rates of spontaneous activity and responded to higher stimulus velocities than the other classes. In these respects, LFNO cells resembled the layer V cells of area 17 in the cat and the layer V and VI cells of area 17 in the monkey that project to the superior colliculus. Horseradish peroxidase was injected into the superior colliculus and determined that corticotectal cells in the mouse were located in layer V, the layer where LFNO cells were recorded. Additional evidence that some LFNO cells project to the superior colliculus was provided by preliminary experiments in which the superior colliculus was stimulated and cortical cells with LFNO receptive fields were antidromically activated. Neurons with LFNO receptive fields constitute a class that is functionally distinct, with cell bodies that are located in a single layer (V) of area 17 in the mouse.