Adrenal corticosteroid biosynthesis, metabolism, and action
Adrenal corticosteroid biosynthesis, metabolism, and action
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DOI：
10.1016/j.ecl.2005.01.002
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发表时间：
2005-06-01
影响因子：
4.5
通讯作者：
Stewart, PM
中科院分区：
文献类型：
--
作者：
Arlt, W;Stewart, PM
肾上腺皮质类固醇激素是生命所必需的，如果医生要有效地诊断和治疗患有库欣综合征的患者，就必须了解其合成、分泌和正常生理作用模式的机制。在每种情况下，近年来在知识基础方面都有临床上的重大进展，特别是在类固醇生成，皮质醇作用和代谢的理解方面。本文介绍了皮质类固醇的生物合成，代谢和行动。
Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.