DRD4 exon IIIVNTR polymorphism-susceptibility factor for heroin dependence?: Results of a case-control and a family-based association approach
DRD4 exon IIIVNTR polymorphism-susceptibility factor for heroin dependence?: Results of a case-control and a family-based association approach
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DOI：
10.1038/sj.mp.4000583
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发表时间：
2000-01-01
影响因子：
11
通讯作者：
Maier, W
中科院分区：
文献类型：
--
作者：
Franke, P;Nöthen, MM;Maier, W
多巴胺能异常与药物滥用的发病机制有关。(1)最近，有两份报告表明阿片类药物依赖与多巴胺D-4受体（DRD 4）基因外显子III VNTR的长等位基因的存在之间存在关联。（2，3）我们尝试使用独立病例对照和基于家族的关联样本的双层策略来复制这一发现。我们的研究可能是迄今为止最大的关于阿片类药物依赖的候选基因关联研究，样本包括815名受试者，其中396名是患者。我们发现DRD 4外显子III VNTR的长等位基因在285名海洛因成瘾者和197名对照中的频率相似。此外，在111名患者及其父母的样本中，未观察到长等位基因向受影响后代的优先传递。因此，我们的研究结果不支持DRD 4外显子III VNTR等位基因是阿片类药物依赖的易感因素的假设。
Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.(1) Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the dopamine D-4 receptor (DRD4) gene exon III VNTR.(2,3) We have attempted to replicate this finding using a two-tiered strategy employing independent case-control and family-based association samples. Our study was possibly the largest candidate gene association study to date on opioid dependence in a sample of 815 subjects, 396 of whom were patients. We found long alleles of the DRD4 exon III VNTR in similar frequency among 285 heroin addicts and 197 controls. Furthermore, no preferential transmission of long alleles to affected offspring was observed in a sample of 111 patients and their parents. Our results, therefore, do not support the hypothesis that alleles of the DRD4 exon III VNTR are susceptibility factors for opioid dependence in man.