Risk of ovarian cancer in relation to use of phenolphthalein-containing laxatives.

Risk of ovarian cancer in relation to use of phenolphthalein-containing laxatives.
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DOI:
10.1054/bjoc.2000.1250
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发表时间:
2000-08
影响因子:
8.8
通讯作者:
Ness RB
Ness RB
中科院分区:
医学1区
文献类型:
--
作者:
Cooper GS;Longnecker MP;Sandler DP;Ness RB

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我们在 410 例上皮性卵巢癌病例和 713 例对照中检查了与使用含酚酞泻药相关的卵巢癌风险。与从未使用过泻药的女性相比,曾经使用过含有酚酞的泻药与卵巢癌风险增加无关(比值比,OR,1.1,95%置信区间,CI,0.9-1.4)。使用越频繁,风险略有增加,但不显着(使用 75 天或以上的 OR 1.2)。当使用不含酚酞泻药的女性作为参考组时,相关性略有增加,但没有显着增大(任何使用含酚酞泻药的 OR 1.4,使用 75 天或以上的 OR 1.5) © 2000 Cancer Research Campaign
We examined ovarian cancer risk in relation to use of phenolphthalein-containing laxatives in 410 epithelial ovarian cancer cases and 713 controls. Compared to women who never used a laxative, ever use of a phenolphthalein-containing laxative was not associated with an increased risk of ovarian cancer (odds ratio, OR, 1.1, 95% confidence interval, CI, 0.9–1.4). Risk was slightly, but not significantly, higher with more frequent use (OR 1.2 for 75 or more days of use). When women who used non-phenolphthalein containing laxatives was used as the reference group, the associations were slightly, but not significantly larger (OR 1.4 for any use of phenolphthalein-containing laxatives and OR 1.5 for 75 or more days of use) © 2000 Cancer Research Campaign
DOI: 10.7326/0003-4819-99-1-14
发表时间: 1983-01-01
影响因子: 39.2
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