Clearance of apoptotic neutrophils and resolution of inflammation.
Clearance of apoptotic neutrophils and resolution of inflammation.
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DOI：
10.1111/imr.12453
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发表时间：
2016-09
影响因子：
8.7
通讯作者：
Greenlee-Wacker MC
中科院分区：
文献类型：
--
作者：
Greenlee-Wacker MC
吞噬细胞吞噬凋亡细胞，这一过程被称为胞吞作用，对于维持正常组织稳态至关重要，也是消退炎症的先决条件。中性粒细胞是人体中主要的循环白细胞，含有大量能够杀死和降解微生物的有毒物质。中性粒细胞寿命较短，会因细胞凋亡而自发死亡。本综述将重点介绍人类吞噬细胞如何吞噬凋亡中性粒细胞、吞噬细胞群体的异质性如何影响胞吞信号传导以及胞吞作用的下游后果。巨噬细胞对凋亡中性粒细胞的胞吞作用可促进抗炎信号传导，防止中性粒细胞裂解并抑制免疫反应。鉴于胞吞作用的免疫调节特性，了解调节和增强胞吞作用的途径可用于对抗感染和慢性炎症。
The engulfment of apoptotic cells by phagocytes, a process referred to as efferocytosis, is essential for maintenance of normal tissue homeostasis and a prerequisite for the resolution of inflammation. Neutrophils are the predominant circulating white blood cell in humans, and contain an arsenal of toxic substances that kill and degrade microbes. Neutrophils are short lived and spontaneously die by apoptosis. This review will highlight how the engulfment of apoptotic neutrophils by human phagocytes occurs, how heterogeneity of phagocyte populations influences efferocytosis signaling, and downstream consequences of efferocytosis. The efferocytosis of apoptotic neutrophils by macrophages promotes anti-inflammatory signaling, prevents neutrophil lysis, and dampens immune responses. Given the immunomodulatory properties of efferocytosis, understanding pathways that regulate and enhance efferocytosis could be harnessed to combat infection and chronic inflammatory conditions.
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影响因子：
3.7
作者：
Alfaro C;Suarez N;Oñate C;Perez-Gracia JL;Martinez-Forero I;Hervas-Stubbs S;Rodriguez I;Perez G;Bolaños E;Palazon A;Sanmamed MF;Morales-Kastresana A;Gonzalez A;Melero I
通讯作者：
Melero I
影响因子：
5.4
作者：
Aleman, Mercedes;de la Barrera, Silvia;Sasiain, Maria
通讯作者：
Sasiain, Maria
影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
影响因子：
5.5
作者：
Buckley, Christopher D.;Ross, Ewan A.;Rainger, G. Ed
通讯作者：
Rainger, G. Ed
影响因子：
4.4
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM