The RNA-Recognition Pathway: An Overlooked Transportation Mechanism for Extracellular and Therapeutic RNAs
The RNA-Recognition Pathway: An Overlooked Transportation Mechanism for Extracellular and Therapeutic RNAs
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DOI：
10.1089/genbio.2023.0049
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发表时间：
2023-12
期刊：
影响因子：
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通讯作者：
Alice Ghidini;Aleksandra Singh
中科院分区：
文献类型：
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作者：
Alice Ghidini;Aleksandra Singh
在弗朗西斯克里克于1958年提出的中心法则中，RNA只是在DNA和蛋白质表达之间起中介作用。在过去的几十年里，我们对RNA形式和功能多样性的理解大大增加。今天RNA研究的许多前沿之一是将其范围扩展到质膜之外，并探索RNA在细胞外的作用。从这个角度来看，我们将突出RNA在细胞外空间中的作用的关键证据，讨论细胞外RNA转运机制的新研究，以及将这些发现转化为有效和广泛有用的临床生物技术的潜在影响。
In the central dogma proposed by Francis Crick in 1958, RNA simply plays an intermediary role between DNA and protein expression. Over the last few decades, our understanding of the diversity of RNA forms and functions has vastly increased. One of the many frontiers of RNA research today is expanding its scope beyond the confines of the plasma membrane and exploring the roles of RNA outside of the cell. In this perspective, we will highlight the key evidence for RNA's role in the extracellular space, discuss new research on the mechanisms of extracellular RNA transport, and the potential impact of translating these discoveries into an effective and broadly useful clinical biotechnology.