A frequency-amplitude coordinator and its optimal energy consumption for biological oscillators.
A frequency-amplitude coordinator and its optimal energy consumption for biological oscillators.
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生物振荡器的频幅协调器及其最优能耗
DOI：
10.1038/s41467-021-26182-2
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发表时间：
2021-10-08
影响因子：
16.6
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Qin BW;Zhao L;Lin W
包括神经元放电和蛋白- mrna相互作用在内的生物节律是具有扩散作用的基本活动。它们均衡的时空动态有利于健康的可持续性。因此，校准生物节律的异常频率和幅度可以防止生理功能障碍或疾病。然而，许多工作专门用于调制频率，而振幅通常被忽略，尽管这两个量对于协调生物功能和输出同样重要。特别是，目前还缺乏一种可行的同时精确协调这两个量的方法。在这里，我们首次提出了一种通用方法，通过动态系统工具严格设计频率-幅度协调器。我们同时考虑了空间和时间信息。通过一个精心设计的协调器，它们可以同时精确地校准到所需的水平。我们的方法的实用性和有效性在代表性的神经元和基因调控模型中得到了证明。进一步揭示其基本机制和最佳能量消耗，为今后生物节律调控提供启示。
Biorhythm including neuron firing and protein-mRNA interaction are fundamental activities with diffusive effect. Their well-balanced spatiotemporal dynamics are beneficial for healthy sustainability. Therefore, calibrating both anomalous frequency and amplitude of biorhythm prevents physiological dysfunctions or diseases. However, many works were devoted to modulate frequency exclusively whereas amplitude is usually ignored, although both quantities are equally significant for coordinating biological functions and outputs. Especially, a feasible method coordinating the two quantities concurrently and precisely is still lacking. Here, for the first time, we propose a universal approach to design a frequency-amplitude coordinator rigorously via dynamical systems tools. We consider both spatial and temporal information. With a single well-designed coordinator, they can be calibrated to desired levels simultaneously and precisely. The practical usefulness and efficacy of our method are demonstrated in representative neuronal and gene regulatory models. We further reveal its fundamental mechanism and optimal energy consumption providing inspiration for biorhythm regulation in future.
影响因子：
3.7
作者：
Terry AJ;Sturrock M;Dale JK;Maroto M;Chaplain MA
通讯作者：
Chaplain MA