Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest
Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest
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DOI：
10.1161/01.res.0000049104.57549.03
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发表时间：
2003-01-10
影响因子：
20.1
通讯作者：
Canty, JM
中科院分区：
文献类型：
--
作者：
Fallavollita, JA;Malm, BJ;Canty, JM
冬眠心肌的特征是静息时血流和功能减少，对外部负荷增加的反应是有限的收缩储备。我们假设这种功能的衰减反映了一种适应性下调，这种下调阻止了应激过程中缺血代谢证据的发展。为了验证这一假设，猪被慢性植入近端左前降支动脉狭窄3个月，导致严重的前心尖运动功能减退，静息灌注减少（远端为0.78+/-0.05 vs 0.94+/-0.07 mL.min（-1）.g（-1），P
Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic evidence of ischemia during stress. To test this hypothesis, pigs were chronically instrumented with a proximal left anterior descending artery stenosis for 3 months, resulting in severe anteroapical hypokinesis with reduced resting perfusion (0.78+/-0.05 versus 0.94+/-0.07 mL.min(-1).g(-1) in remote, P