A clonal Plasmodium falciparum population in an isolated outbreak of malaria in the Republic of Cabo Verde
A clonal Plasmodium falciparum population in an isolated outbreak of malaria in the Republic of Cabo Verde
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DOI：
10.1017/s0031182099003972
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发表时间：
1999-04-01
期刊：
影响因子：
2.4
通讯作者：
do Rosario, VE
中科院分区：
文献类型：
--
作者：
Arez, AP;Snounou, G;do Rosario, VE
我们提出了第一个寄生虫学，分子和纵向分析孤立的疟疾暴发。这次疫情发生在圣地亚哥岛（佛得角共和国），该地区疟疾是低流行并得到控制的，因此人们被认为没有免疫力。在1个月内和次年的横断面调查中采集了居民的血液样本。采用聚合酶链反应（PCR）测定寄生虫的存在和性质。仅检出恶性疟原虫。遗传分析表明，该寄生虫在遗传上是同质的，可能是无性系的。配子体在这一时期被发现。我们的数据表明，这是一次局灶性暴发，导致至少40%的村民感染了克隆寄生虫系。因此，在相当大比例（10%）的宿主中，恶性疟原虫感染可持续至少1年。讨论了对疟疾控制和流行病学数据解释的影响。
We present the first parasitological, molecular and longitudinal analysis of an isolated outbreak of malaria. This outbreak occurred on Santiago Island (Republic of Cabo Verde), a region where malaria is hypoendemic and controlled, and thus the population is considered non-immune. Blood samples were collected from the inhabitants over 1 month and during cross-sectional surveys in the following year. The presence and nature of the parasites was determined by PCR. Plasmodium falciparum was the only species detected. Genetic analysis revealed that the circulating parasites were genetically homogeneous, and probably clonal. Gametocytes were found throughout this period. Our data suggest that this represented a focal outbreak, resulting in the infection of at least 40 % of the villagers with a clonal parasite line. Thus, P. falciparum infections can persist for at least 1 year in a substantial proportion (10 %,) of the hosts. Implications for malaria control and the interpretation of epidemiological data are discussed.