Plasma cells in chronic endometritis are easily identified when stained with syndecan-1
Plasma cells in chronic endometritis are easily identified when stained with syndecan-1
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DOI：
10.1038/modpathol.3880405
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发表时间：
2001-09-01
期刊：
影响因子：
7.5
通讯作者：
Korourian, S
中科院分区：
文献类型：
--
作者：
Bayer-Garner, IB;Korourian, S
背景：慢性子宫内膜炎发生在3-10%接受子宫内膜活检的不规则子宫出血患者中。慢性子宫内膜炎的诊断依赖于对子宫内膜浆细胞的识别。组织可能显示出突出的梭形细胞基质成分，并且通常难以确定日期。Syndecan-1是一种细胞表面蛋白聚糖，在浆细胞的细胞表面表达。设计图：对18例诊断为慢性子宫内膜炎的子宫内膜刮除病例和25例功能失调性子宫出血的子宫内膜刮除病例进行了审查，这些病例均为35岁以下女性，未观察到其他组织病理学变化，检查是否存在浆细胞。然后将切片用syndecan-1染色。结果：所有慢性胰腺炎患者的浆细胞膜均可见syndecan-1染色。在苏木精和伊红染色或syndecan-1染色切片中，功能失调性子宫出血病例均未显示浆细胞的存在。结论.在苏木精和伊红染色载玻片上未发现浆细胞的疑似慢性腹膜炎病例中，syndecan-1可能是鉴定浆细胞的有效辅助手段，从而有助于慢性腹膜炎的诊断。
Background: Chronic endometritis has been observed in 3-10% of women with irregular uterine bleeding who undergo endometrial biopsy. The diagnosis of chronic endometritis rests on the recognition of plasma cells in endometrial. tissue that may show a prominent spindle cell stromal component, and is frequently difficult to date. Syndecan-1 is a cell-surface proteoglycan that is expressed on the cell surface of plasma cells. Design: Eighteen endometrial curettage cases with the diagnosis of chronic endometritis and 25 endometrial curettage cases of dysfunctional uterine bleeding, in females under the age of thirty-five in whom no other histopathologic changes were noted, were reviewed for the presence of plasma cells. Sections were then stained with syndecan-1. Results: All of the chronic endometritis cases showed easily visible syndecan-1 staining of plasma cell membranes. None of the cases of dysfunctional uterine bleeding showed presence of plasma cells in either the hematoxylin and eosin stained or syndecan-1 stained sections. Conclusions. In cases of suspected chronic endometritis in which no plasma cells can be found on hematoxylin and eosin stained slides, syndecan-1 may be an effective adjunct in the identification of plasma cells and thus aid in the diagnosis of chronic endometritis.