XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013
XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013
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2013 年第十三届地中海医学和生物工程与计算会议
DOI：
10.1007/978-3-319-00846-2_142
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Abásolo D
中科院分区：
文献类型：
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作者：
Abásolo D
神经元输出是兴奋性和抑制性成分动态整合的复杂信号。神经元网络中突触抑制的减少增加了神经元的兴奋性和多个尖峰。神经元群体之间的同步多个尖峰进一步产生节律性场电位，并且这种癫痫样活动可以在大脑中传播并引起癫痫发作。降低癫痫样活动节律性的药物干预可能具有抗癫痫潜力。我们评估了Lempel-Ziv（LZ）的复杂性，以确定在体外小鼠齿状回颗粒细胞中记录的群体尖峰的节律性。阻断GABA A受体拮抗剂荷包牡丹碱的突触抑制，引起癫痫样群体尖峰，我们发现LZ信号的复杂性显着降低。此外，GABA受体激动剂巴氯芬降低了癫痫样群体峰电位的幅度，我们发现它增加了LZ的复杂性。结果表明，LZ的复杂性是敏感的药物干预，明显改变节律的神经元输出的desertifizing神经元群体放电。这种神经元信号处理的新方法可用于识别新的抗癫痫靶点。
Neuronal outputs are complex signals of dynamically integrated excitatory and inhibitory components. Decreased synaptic inhibition in a neuronal network increases excitability and multiple spiking in neurons. Synchronized multiple spiking among a neuronal population further generates rhythmic field potentials and this epileptiform activity can propagate in the brain and cause seizures. Pharmacological interventions that reduce rhythmicity of epileptiform activity may have antiepileptic potentials. We evaluated the Lempel-Ziv (LZ) complexity for identifying rhythmicity in population spikes recorded in granule cells of the murine dentate gyrusin vitro. Blocking synaptic inhibition by the GABAAreceptor antagonist, bicuculline, caused epileptiform population spikes, and we found that the LZ complexity of the signal was significantly reduced. Moreover, the GABABreceptor agonist, baclofen, reduced the amplitude of the epileptiform population spike and we found that it increased LZ complexity. The results show that LZ complexity is sensitive to pharmacological interventions that apparently alter rhythmicity of neuronal outputs by desynchronizing neuronal population firing. This novel approach in neuronal signal processing may be used to identify new antiepileptic targets.