Cytomegalovirus immune plasma in bone marrow transplant recipients.
Cytomegalovirus immune plasma in bone marrow transplant recipients.
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DOI：
10.7326/0003-4819-97-1-11
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发表时间：
1982-07
影响因子：
39.2
通讯作者：
D. Winston;R. Pollard;W. Ho;J. Gallagher;L. Rasmussen;Shena Nan-Ying Huang;Cheng-Hsien Lin;Thomas G. Gossett;T. Merigan;R. Gale
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文献类型：
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作者：
D. Winston;R. Pollard;W. Ho;J. Gallagher;L. Rasmussen;Shena Nan-Ying Huang;Cheng-Hsien Lin;Thomas G. Gossett;T. Merigan;R. Gale
被动免疫对骨髓移植中巨细胞病毒感染和间质性肺炎的影响在一项随机对照试验中进行了评估。24例患者在移植前后接受巨细胞病毒免疫血浆，24例患者为对照。尽管对照组和血浆组的巨细胞病毒感染发生率相似，但接受血浆的组中症状性感染（12/24 vs 5/24，p = 0.07）和间质性肺炎（11/24 vs 5/24，p = 0.12）的发生率较低。巨细胞病毒感染发生在13例白细胞输注者中的11例和35例未接受白细胞输注的患者中的16例（p = 0.02）。在未接受白细胞输注的患者中，对照组和血浆组的巨细胞病毒感染发生率相似，但接受血浆组的症状性感染（18例中的8例与17例中的1例，p = 0.03）和间质性肺炎（18例中的9例与17例中的1例，p = 0.01）显著较少。这些结果表明，被动免疫修改人类巨细胞病毒感染，并防止骨髓移植间质性肺炎，特别是当不使用白细胞输注。
The effects of passive immunization on cytomegalovirus infection and interstitial pneumonia in marrow transplants were evaluated in a randomized, controlled trial. Twenty-four patients received cytomegalovirus immune plasma before and after transplantation, and 24 patients were controls. Although the incidence of cytomegalovirus infection was similar in the control and plasma groups, symptomatic infection (12 of 24 versus five of 24, p = 0.07) and interstitial pneumonia (11 of 24 versus five of 24, p = 0.12) occurred less frequently in the group receiving plasma. Cytomegalovirus infection occurred in 11 of 13 recipients of leukocyte transfusions and in 16 of 35 patients not given leukocyte transfusions (p = 0.02). Among patients not given leukocyte transfusions, the incidence of cytomegalovirus infection was similar in the control and plasma groups, but symptomatic infection (eight of 18 versus one of 17, p = 0.03) and interstitial pneumonia (nine of 18 versus one of 17, p = 0.01) were significantly less in the group receiving plasma. These results suggest that passive immunization modifies cytomegalovirus infection in humans and prevents interstitial pneumonia in marrow transplants especially when leukocyte transfusions are not used.