Participation of the hypothalamus-hypophysis axis in the sympathetic activation of human obesity
Participation of the hypothalamus-hypophysis axis in the sympathetic activation of human obesity
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DOI：
10.1161/hy1201.096117
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发表时间：
2001-12-01
期刊：
影响因子：
8.3
通讯作者：
Mancia, G
中科院分区：
文献类型：
--
作者：
Grassi, G;Seravalle, G;Mancia, G
以往的研究表明，下丘脑和垂体因子参与了各种实验室刺激引起的急性交感兴奋。交感神经激活的慢性疾病，如人类肥胖的特征，是否也依赖于这些因素从未被研究过。在40名血压正常的肥胖受试者（[平均+/-SEM]年龄，39.1 ± 0.8岁）中，我们测量了血压（Finapres）、心率（ECG）和节后肌肉交感神经活动（MSNA）（显微神经造影术）。在20名受试者中，根据双盲随机序列，在午夜口服地塞米松（1 mg）（n = 10）或安慰剂（n = 10）后重复测量，而在其余受试者中，在每天晚上口服1 mg地塞米松（n = 10）或安慰剂（n = 10）1周后再次进行测量。在16名年龄匹配的瘦血压正常者中进行了相同的方案。在两组中，急性地塞米松给药显著降低血浆皮质醇（放射免疫测定法），而不影响血流动力学和神经变量。与急性给药相比，在肥胖受试者中，延长地塞米松给药时间，虽然不影响血压和心率，但显著降低血浆皮质醇（从16.0 +/- 1.3降至0.7 +/- 0.1 mug/dL，P
Previous studies have shown that hypothalamic and hypophyseal factors are involved in the acute sympathoexcitation induced by a variety of laboratory stimuli. Whether a chronic condition of sympathetic activation, such as that characterizing human obesity, is also dependent on these factors has never been investigated. In 40 normotensive obese subjects ([mean+/-SEM] age, 39.1 +/- 0.8 years) we measured blood pressure (Finapres), heart rate (ECG), and postganglionic muscle sympathetic nerve activity (MSNA) (microneurography). In 20 subjects measurements were repeated, according to a double-blind randomized sequence, after a midnight oral dose of dexamethasone (1 mg) (n = 10) or placebo (n = 10), while in the remaining subjects they were performed again after 1 week of a daily evening oral administration of 1 mg of dexamethasone (n = 10) or placebo (n = 10). The same protocol was performed in 16 age-matched lean normotensives. In both groups acute dexamethasone administration markedly reduced plasma cortisol (radioimmunoassay), without affecting hemodynamic and neural variables. In contrast to the acute administration, in obese subjects prolonged dexamethasone administration, although not affecting blood pressure and heart rate, significantly reduced both plasma cortisol (from 16.0 +/- 1.3 to 0.7 +/- 0.1 mug/dL, P