Studies Toward Elucidating the Stereochemical Structure of Iriomoteolide 1a
Studies Toward Elucidating the Stereochemical Structure of Iriomoteolide 1a
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DOI：
10.1055/s-0031-1290357
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发表时间：
2012-03-01
期刊：
影响因子：
2
通讯作者：
Yang, Jiong
中科院分区：
文献类型：
--
作者：
Huang, Jinhua;Yang, Jiong
A diastereomer of iriomoteolide 1a has been synthesized as part of our effort to identify the so far unknown stereochemical structure of the natural product. The synthetic route features a lithium acetylide-chloroformate coupling, the ring-closing metathesis to form the macrocyclic diolide, and a SmI2-mediated intramolecular reductive allylation for formation of the cyclic hemiketal.
