Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice
Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice
复制标题
小鼠急性淋巴细胞脉络膜脑膜炎病毒感染前三天诱导的异特异性细胞毒性细胞活性
作者：
R. Welsh;R. Zinkernagel
淋巴细胞性脉络丛脑膜炎病毒（LCMV）急性感染成年小鼠可诱导几种类型的免疫应答。H-2限制性病毒特异性细胞毒性T细胞在感染后第5 - 6天可被证实，并在第7 - 10天达到峰值1 -5。免疫复合物中的抗病毒抗体首先在感染后4 d检测到6，7，并且非特异性激活的巨噬细胞可以在4至5 d后被证实（参考文献3和8）。我们在这里报告，急性LCMV感染elections的生产或激活的另一种类型的细胞毒性细胞，早在1天后感染。这些早期细胞毒性细胞以一定的特异性裂解感染或未感染的同系、同种异体和异种细胞系。这些效应细胞不属于迄今为止涉及对LCMV感染的免疫应答的细胞类型，并且具有自然杀伤细胞的许多特性。
ACUTE infection of adult mice with lymphocytic choriomeningitis virus (LCMV) induces several types of immune responses. H–2-restricted virus-specific cytotoxic T cells are demonstratable from day 5 to 6 and peak on day 7 to 10 post-infection1–5. Antiviral antibody in immune complexes is first detected by 4 d post infection6,7, and non-specifically activated macrophages can be demonstrated after 4 to 5 d (refs 3 and 8). We report here that the acute LCMV infection elicits the production or activation of another type of cytotoxic cell as early as 1 d post infection. These early cytotoxic cells lyse infected or uninfected syngenetic, allogeneic, and xenogeneic cell lines with some specificity. These effector cells do not belong to the cell types thus far implicated in the immune response to LCMV infection and have many of the properties of natural killer cells.