PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA.
PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA.
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发表时间：
2016-03
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通讯作者：
A. Verkhratsky;R. Zorec;Jose Julio Rodriguez;V. Parpura
中科院分区：
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作者：
A. Verkhratsky;R. Zorec;Jose Julio Rodriguez;V. Parpura
主要影响人类的神经退行性疾病的共同点是神经细胞的进行性死亡，导致神经和认知障碍。星形胶质细胞是中枢神经系统内稳态、防御和再生的中心成分，它们的功能障碍或反应性参与了神经退行性疾病的病理生理学。在神经退行性变的背景下，星形胶质细胞的病理重塑是多方面的。在几乎所有形式的神经退行性疾病中都发现了星形胶质细胞萎缩和功能丧失的星形胶质细胞反应性。星形胶质细胞可能是旨在预防和可能治疗神经退行性疾病的治疗策略的新靶点。
The common denominator of neurodegenerative diseases, which mainly affect humans, is the progressive death of neural cells resulting in neurological and cognitive deficits. Astroglial cells are the central elements of the homoeostasis, defence and regeneration of the central nervous system, and their malfunction or reactivity contribute to the pathophysiology of neurodegenerative diseases. Pathological remodelling of astroglia in neurodegenerative context is multifaceted. Both astroglial atrophy with a loss of function and astroglial reactivity have been identified in virtually all the forms of neurodegenerative disorders. Astroglia may represent a novel target for therapeutic strategies aimed at preventing and possibly curing neurodegenerative diseases.