Alternative types of duodenal ulcer induced in mice by partial X irradiation of the thorax.
Alternative types of duodenal ulcer induced in mice by partial X irradiation of the thorax.
复制标题
胸部部分 X 射线照射引起小鼠十二指肠溃疡的其他类型。
DOI：
10.2307/3576073
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发表时间：
1983
影响因子：
3.4
通讯作者：
J. A. Silvester
中科院分区：
文献类型：
--
作者：
A. Michalowski;S. Uehara;W. Yin;J. Burgin;J. A. Silvester
[译文]目前的研究扩展了我们早期的观察。Michalowski, Br。中华放射医学杂志，2003,17 (2)；A. Michalowski和J. Burgin，《放射肿瘤学进展》，第105-110页]胸部辐照的雌性CFLP小鼠的胃肠道病理。研究表明，下纵隔暴露于单剂量14-30 Gy的X射线可导致十二指肠近端溃疡的形成，并经常伴有胃窦黏膜的侵蚀。胸椎外侧野X光照射可引起十二指肠乳头附近的单一溃疡，常伴有胃底黏膜的边界变性。鉴于消化道膈下部分接受的辐射量很小，这些胃-十二指肠病变代表了胸廓辐射的体外效应。
The present study extends our earlier observations [A. Michalowski, Br. J. Radiol. 54, 713 (1981); A. Michalowski and J. Burgin, in Progress in Radio-Oncology II, pp. 105-110] on gastrointestinal pathology in thorax-irradiated female CFLP mice. It shows that exposure of the lower mediastinum to single doses of 14-30 Gy X rays results in the formation of the proximal duodenal ulcer accompanied frequently by erosion of the antral gastric mucosa. X irradiation of the lateral thoracic fields is responsible for single ulcers in the proximity of duodenal papilla, often associated with a circumscribed area of degeneration of the fundic mucosa of the stomach. In view of the small amount of radiation received by the subdiaphragmatic parts of the alimentary tract, these gastro-duodenal lesions represent abscopal effects of thoracic irradiation.