Overexpression and significance of focal adhesion kinase in hepatocellular carcinoma and its relationship with HBV infection
Overexpression and significance of focal adhesion kinase in hepatocellular carcinoma and its relationship with HBV infection
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DOI：
10.1007/s12032-008-9137-0
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发表时间：
2009-12-01
期刊：
影响因子：
3.4
通讯作者：
Li, Xiaowu
中科院分区：
文献类型：
--
作者：
Cai, Lei;Han, Juan;Li, Xiaowu
肝细胞癌的侵袭和转移影响其预后。HBV感染与许多致癌基因相互作用，是HCC的高危因素。局灶黏附激酶（FAK）是一种新的癌基因，其过度表达在包括HCC在内的许多癌症的发生和进展中起重要作用。然而，HBV感染与FAK对HCC预后的关系尚不清楚。回顾性研究了89例经组织学证实的HCC患者的档案标本。免疫组化检测FAK的表达。结合肝细胞癌指标，特别是HBsAg和HBV DNA，分析FAK的表达。38/89的肿瘤中检测到FAK过表达。HCC中FAK过表达与HBsAg （P = 0.033）、HBV DNA水平（P = 0.005）、HCC血管浸润（P = 0.000*）、TNM分期（P = 0.003）显著相关。与FAK表达阴性的患者相比，FAK阳性患者的生存率较低。FAK的过表达可能与HBV感染相关，并有助于HCC的进展，这提高了FAK过表达作为HCC预后不良的潜在标志的可能性。
The prognosis of the hepatocellular carcinoma is influenced by its invasion and metastasis. Interacting with a number of oncogenes, HBV infection is a high risk factor for HCC. Overexpression of Focal adhesion kinase (FAK), a novel oncogene, has been suggested to play an important role in tumorigenesis and progression of many cancers, including HCC. However, the relationship between HBV infection and FAK for HCC prognosis is still unclear. A retrospective study of 89 archival specimens of subjects with histologically confirmed HCC was carried out. Immunohistochemistry was utilized to examine the expression of FAK. Then the FAK expression was analyzed with index of HCC, especially with HBsAg and HBV DNA. FAK overexpression was detected in 38/89 of the tumors. FAK overexpression in HCC significantly correlated with HBsAg (P = 0.033), HBV DNA level (P = 0.005), vascular invasion of HCC (P = 0.000*), and TNM stage (P = 0.003). FAK-positive patients exhibited a lower survival rate compared with those with negative FAK expression. Overexpression of FAK might have a correlation with HBV infection and contribute to HCC progression, raising the possibility of FAK overexpression as a potential marker for a poor prognosis in HCC.