Calcium signaling and apoptosis
Calcium signaling and apoptosis
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DOI：
10.1016/s0006-291x(03)00616-8
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发表时间：
2003-05-09
影响因子：
3.1
通讯作者：
Madesh, M
中科院分区：
文献类型：
--
作者：
Hajnóczky, G;Davies, E;Madesh, M
Ca 2+是细胞存活的关键调节因子之一，但Ca 2+也可诱导细胞凋亡以响应多种病理条件。Ca 2+的促凋亡作用是由多种Ca 2+敏感因子介导的，这些因子分布在各种细胞内细胞器中，包括ER、细胞质和线粒体。这些细胞器的Ca 2+动力学似乎是由凋亡调节Bcl-2家族蛋白调制的。本文综述了近年来钙离子调控细胞凋亡的机制以及Bcl-2家族蛋白与钙储存细胞器相互作用的研究进展。(C)2003 Elsevier Science（美国）。All rights reserved.
Ca2+ is one of the key regulators of cell survival, but Ca2+ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca2+ are mediated by a diverse range of Ca2+-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca2+ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca2+ and the interactions of Bcl-2 family proteins with the Ca2+ storage organelles are discussed. (C) 2003 Elsevier Science (USA). All rights reserved.