Herpesvirus-induced atherosclerosis in chickens.
Herpesvirus-induced atherosclerosis in chickens.
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发表时间：
1983-05
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通讯作者：
C. Fabricant;J. Fabricant;C. Minick;M. M. Litrenta-M.
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作者：
C. Fabricant;J. Fabricant;C. Minick;M. M. Litrenta-M.
反复的实验已经证实，马立克氏病疱疹病毒（MDV）感染导致无特定病原体（SPF）胆固醇正常的鸡动脉粥样硬化。正常胆固醇血症和高胆固醇血症的未感染SPF鸡都不会发生这种疾病。MDV引起的动脉疾病与人类慢性动脉粥样硬化非常相似。胆固醇和饱和胆固醇酯在培养的MDV感染的动脉平滑肌细胞（SMC）中积累。在体内进行了类似的初步观察。这些结果表明，MDV诱导的SMC脂质代谢的改变是MDV诱导的动脉粥样硬化的发病机制中的重要。此外，商业上用于预防MDV诱导的鸡肿瘤的火鸡疱疹病毒免疫也可预防MDV诱导的动脉粥样硬化。这种动物模型在动脉粥样硬化研究中引入了重要的新维度和工具：一种确定的病原体（MDV），其在已知对病原体具有遗传易感性的确定动物中引起动脉粥样硬化。利用这些工具，可以在相对较短的时间内建立动脉粥样硬化发病机制的重要机制。此外，这种动物模型应该被认为是重要的动脉粥样硬化研究的其他模型，因为疱疹病毒感染是普遍存在于这些动物。最后，由于人类广泛和持续感染多达五种疱疹病毒，这些研究可能会导致人类动脉粥样硬化的理解和最终控制。
Repeated experiments have established that infection with Marek's disease herpesvirus (MDV) leads to atherosclerosis in specific pathogen free (SPF) normocholesterolemic chickens. Neither normocholesterolemic nor hypercholesterolemic uninfected SPF chickens develop this disease. The MDV-induced arterial disease is remarkably similar to chronic human atherosclerosis. Cholesterol and saturated cholesteryl esters accumulated in cultured arterial smooth muscle cells (SMC) infected with MDV. Similar preliminary observations were made in vivo. These findings suggest that MDV-induced alteration of SMC lipid metabolism is of major importance in the pathogenesis of MDV-induced atherosclerosis. In addition, immunization with turkey herpesvirus, used commercially to prevent MDV-induced tumors in chickens, also protected against MDV-induced atherosclerosis. This animal model has introduced important new dimensions and tools in atherosclerosis research: a defined etiologic agent (MDV) that causes atherosclerosis in a defined animal of known genetic susceptibility to the etiologic agent. With these tools, important mechanisms in the pathogenesis of atherosclerosis may be established in a relatively short period of time. Further, this animal model should be considered important in other models of atherosclerosis research because herpesvirus infections are ubiquitous in these animals. Finally, because humans are widely and persistently infected with up to five herpesviruses, these studies may lead to the understanding and eventual control of human atherosclerosis.