Recovery of myocardial mechanics in Kawasaki disease demonstrated by speckle tracking and tissue Doppler methods
Recovery of myocardial mechanics in Kawasaki disease demonstrated by speckle tracking and tissue Doppler methods
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DOI：
10.1111/echo.13773
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发表时间：
2018-03-01
影响因子：
1.5
通讯作者：
Pamuk, Utku
中科院分区：
文献类型：
--
作者：
Azak, Emine;Cetin, Ibrahim Ilker;Pamuk, Utku
目的探讨川崎（KD）患儿治疗过程中心肌变形和功能的变化。对左心室（LV）的纵向和周向应变（S）和应变率（SR）以及右心室（RV）的纵向S和SR进行了STE。TDI在室间隔（IVS），LV和RV的基础上进行。结果在TDI参数中，E-m和射血时间（ET）在IVS，ET在LV和ET在RV治疗前获得的KD患者明显低于对照组。治疗后，尽管有所改善，但与对照组相比，KD患者的IVS ET和RV ET仍显着降低。与对照组相比，KD患者治疗前获得的左心室整体纵向和周向S和SR值显著降低。治疗后左心室S和SR值增加。然而，与对照组相比，KD患者的左心室全周S值仍然显著降低。结论KD患者急性期左心室整体S和SR降低，可能是反映心肌炎症反应的敏感指标。这项研究显示，在治疗KD期间，左心室心肌功能逐渐改善。
AimTo investigate myocardial deformation and function during treatment for Kawasaki disease (KD) in children.MethodsWe performed speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI) in 15 children with KD and 15 healthy children during treatment for KD. STE was performed for longitudinal and circumferential strain (S) and strain rate (SR) at the left ventricle (LV) and for longitudinal S and SR at the right ventricle (RV). TDI was performed at the base of interventricular septum (IVS), LV, and RV.ResultsAmong TDI parameters, E-m and ejection time (ET) at IVS, ET at LV and ET at RV obtained obtained before treatment were significantly lower in patients with KD compared to controls. After treatment, in spite of improvements, ET at IVS and ET at RV remained significantly lower in patients with KD compared to controls. Left ventricular global longitudinal and circumferential S and SR values obtained before treatment were significantly lower in patients with KD compared to controls. Left ventricular S and SR values were found to be increased after treatment. However, left ventricular global circumferential S value remained significantly lower in patients with KD compared to controls. There were no significant differences in right ventricular global longitudinal S and SR values between patients and controls before treatment.ConclusionDuring acute phase, patients with KD have reduced global left ventricular S and SR which may be more sensitive indicators of myocardial inflammation. This study showed gradual improvements in left ventricular myocardial function during treatment for KD.