NONINVASIVE ASSESSMENT OF THE AGE-RELATED-CHANGES IN STIFFNESS OF MAJOR BRANCHES OF THE HUMAN ARTERIES
NONINVASIVE ASSESSMENT OF THE AGE-RELATED-CHANGES IN STIFFNESS OF MAJOR BRANCHES OF THE HUMAN ARTERIES
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DOI：
10.1093/cvr/21.9.678
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发表时间：
1987-09-01
影响因子：
10.8
通讯作者：
HIRAI, T
中科院分区：
文献类型：
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作者：
KAWASAKI, T;SASAYAMA, S;HIRAI, T
在39名年龄在6-81岁的受试者中使用超声锁相回波跟踪系统研究了人体动脉主要分支（颈总动脉、腹主动脉、股动脉和肱动脉）的静态力学性能，该系统允许连续经皮测量动脉直径。僵硬度指数根据体循环血压和动脉直径之间的关系计算。随着年龄的增长，所有动脉的直径显著增加，直径变化百分比降低。所有动脉的硬度指数随着年龄的增长而增加;然而，在肱动脉和股动脉中，给定年龄的个体值存在相当大的变化。与年龄相关的僵硬度增加仅在颈总动脉和腹主动脉中具有统计学显著性。虽然周围动脉的机械性能的测量环境的显着影响，计算出的刚度指数不太容易受到这些刺激在中央动脉。这些结果表明，血管活性刺激可明显改变外周肌动脉的硬度指数，并且更深弹性动脉的机械特性提供了关于由老化和动脉硬化引起的变化的足够可靠的信息。所用的新的超声波方法似乎适用于这种分析。
The static mechanical properties of major branches of the human arteries (common carotid artery, abdominal aorta, femoral artery, and brachial artery) were studied in 39 subjects, aged 6-81 years, using an ultrasonic phase locked echo tracking system that allows continuous transcutaneous measurement of the diameter of the artery. The stiffness indices were calculated from the relation between systemic blood pressure and arterial diameter. With advancing age there was a significant increase in the diameter of all arteries associated with a reduction in percentage change in diameter. The stiffness index increased with age in all arteries; however, in the brachial and femoral arteries there was considerable variation in the individual values for a given age. The age associated increase in stiffness was statistically significant only in the common carotid artery and the abdominal aorta. Although the mechanical properties of the peripheral arteries were significantly influenced by the measuring environment, the calculated stiffness indices were less vulnerable to these stimuli in the central arteries. These results indicate that the stiffness indices of the peripheral muscular arteries are modified appreciably by vasoactive stimuli and that the mechanical properties of the deeper elastic arteries provide sufficiently reliable information about changes caused by aging and arteriosclerosis. The new ultrasonic method used appears to be suitable for this analysis.