The effects of lithium and anticonvulsants on brain structure in bipolar disorder
The effects of lithium and anticonvulsants on brain structure in bipolar disorder
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DOI：
10.1111/j.1600-0447.2010.01582.x
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发表时间：
2010-12-01
影响因子：
6.7
通讯作者：
Frangou, S.
中科院分区：
文献类型：
--
作者：
Germana, C.;Kempton, M. J.;Frangou, S.
目的：探讨锂、抗惊厥药和抗精神病药对双相情感障碍（BD）患者脑结构的影响。方法：对74例接受锂或抗惊厥药或抗精神病药长期预防性治疗的BD患者进行横断面结构脑磁共振成像研究，年龄18-65岁。整体和区域灰质、白质和脑脊液体积在治疗组之间进行比较。结果：与所有其他治疗组相比，接受锂治疗的BD患者右侧亚属前扣带回（延伸至下丘脑）、中央后回、海马/杏仁核复合体和左侧脑岛的灰质更大。结论：锂离子治疗对双相障碍患者的大脑结构有显著影响，尤其是与情绪加工相关的边缘/旁边缘区。
Objective: To investigate the effect of lithium, anticonvulsants and antipsychotics on brain structure in bipolar disorder (BD).Method: A cross-sectional structural brain magnetic resonance imaging study of 74 remitted patients with BD, aged 18-65, who were receiving long-term prophylactic treatment with lithium or anticonvulsants or antipsychotics. Global and regional grey matter, white matter, and cerebrospinal fluid volumes were compared between treatment groups.Results: Grey matter in the subgenual anterior cingulate gyrus on the right (extending into the hypothalamus) and in the postcentral gyrus, the hippocampus/amygdale complex and the insula on the left was greater in BD patients on lithium treatment compared to all other treatment groups.Conclusion: Lithium treatment in BD has a significant effect on brain structure particularly in limbic/paralimbic regions associated with emotional processing.