Elevated energy intake is correlated with hyperresponsivity in attentional, gustatory, and reward brain regions while anticipating palatable food receipt
Elevated energy intake is correlated with hyperresponsivity in attentional, gustatory, and reward brain regions while anticipating palatable food receipt
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DOI：
10.3945/ajcn.112.055285
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发表时间：
2013-06-01
影响因子：
7.1
通讯作者：
Stice, Eric
中科院分区：
文献类型：
--
作者：
Burger, Kyle S.;Stice, Eric
背景资料：肥胖与瘦的个人相比，表现出更大的注意力，味觉，和奖励区域的食物线索的反应，但减少奖励区域的反应在食物摄入。然而，据我们所知，研究还没有测试客观测量的热量摄入是否与独立于过量脂肪组织的神经反应性呈正相关。目的：我们测试了一个假设，即客观测量能量摄入，这占基础需求和身体脂肪的百分比，与预期可口食物摄入的神经反应呈正相关，但与健康体重青少年的食物摄入反应呈负相关。设计：参与者（n = 155;平均值+/- SD年龄：15.9 +/- 1.1岁）完成功能性磁共振成像扫描，同时预期并接受可口的食物与无味的溶液进行比较，双标记水评估能量摄入，并评估静息代谢率和身体成分。能量摄入与外侧视皮层和前扣带皮层的激活呈正相关（视觉处理和注意力），额盖在更敏感的感兴趣区域分析中，当预期可口的食物时，初级味觉皮层（primary gustatory cortex）激活更大，当预期可口的食物时，纹状体激活更大。能量摄入量并没有显着相关的nerve responsivity在美味food intake.Conclusions：结果表明，客观测量的能量摄入量，占基础需求和脂肪组织正相关的活动，在注意力，味觉，和奖励区域时，预期美味的食物。虽然这些区域的过度反应可能会增加暴饮暴食的风险，但目前还不清楚这是最初的脆弱性因素还是以前暴饮暴食的结果。
Background: Obese compared with lean individuals show greater attention-, gustatory-, and reward-region responsivity to food cues but reduced reward-region responsivity during food intake. However, to our knowledge, research has not tested whether an objectively measured caloric intake is positively associated with neural responsivity independent of excess adipose tissue.Objective: We tested the hypothesis that objectively measured energy intake, which accounts for basal needs and the percentage of body fat, correlates positively with the neural response to anticipated palatable food intake but negatively with a response to food intake in healthy-weight adolescents.Design: Participants (n = 155; mean +/- SD age: 15.9 +/- 1.1 y) completed functional magnetic resonance imaging scans while anticipating and receiving palatable food compared With a tasteless solution, a doubly labeled water assessment of energy intake, and assessments of resting metabolic rate and body composition.Results: Energy intake correlated positively with activation in the lateral visual and anterior cingulate cortices (visual processing and attention), frontal operculum (primary gustatory cortex) when anticipating palatable food, and greater striatal activation when anticipating palatable food in a more-sensitive region of interest analysis. Energy intake was not significantly related to neural responsivity during palatable food intake.Conclusions: Results indicate that objectively measured energy intake that accounts for basal needs and adipose tissue correlates positively with activity in attentional, gustatory, and reward regions when anticipating palatable food. Although hyperresponsivity of these regions may increase risk of overeating, it is unclear whether this is an initial vulnerability factor or a result of previous overeating.