Hyposalivation and 10-year all-cause mortality in an elderly Japanese population
Hyposalivation and 10-year all-cause mortality in an elderly Japanese population
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DOI：
10.1111/ger.12319
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发表时间：
2018-06-01
期刊：
影响因子：
2
通讯作者：
Miyazaki, Hideo
中科院分区：
文献类型：
--
作者：
Iwasaki, Masanori;Borgnakke, Wenche S.;Miyazaki, Hideo
目的：评价日本老年人唾液流量与全因死亡率的关系。我们假设假说是死亡率的一个标志。背景：唾液分泌不足是一种客观可测量的唾液流量减少，在老年人中非常普遍。它与营养不良和整体健康状况不佳有关。方法：研究人群包括600名社区居住的日本成年人（306名男性和294名女性），基线年龄为70岁。他们接受了刺激唾液流率（SSFR）测量，并在10年的研究期间进行了随访。按性别分层后，使用Cox比例风险回归分析，比较低渗组和非低渗组（即SSFR < 0.7 mL/min）的全因死亡率的风险比。结果：男性低通气的基线患病率为27.8%(85/306)，女性为47.3%（139/294）。在104（27）个月的平均（标准差）随访期间，发生了80例死亡：男性死亡60例（75.0%），女性死亡20例（25.0%）。在对剩余牙齿数量、吸烟状况、运动、低白蛋白血症、糖尿病和心血管疾病进行校正后，基线时的低唾液含量与男性全因死亡率显著相关（校正后的风险比为1.71；95%可信区间为1.01-2.89）。相反，SSFR与女性全因死亡率之间不存在关联。结论：低通气可能是日本老年社区男性全因死亡率的一个标志。未来研究SSFR和病因特异性死亡率之间的关系是有必要的。
Objective: To evaluate the association of salivary flow rate with all-cause mortality among older Japanese adults. We hypothesised that hyposalivation would be a marker for mortality.Background: Hyposalivation, which is an objectively measurable decrease in salivary flow, is highly prevalent among older adults. It is associated with malnutrition and poor general health.Methods: The study population comprised 600 community-dwelling Japanese adults (306 men and 294 women), who were 70 years old at baseline. They underwent stimulated salivary flow rate (SSFR) measurements and were followed up during a 10-year study period. After stratification by sex, the hazard ratios of all-cause mortality were estimated using Cox proportional hazards regression analysis comparing groups with and without hyposalivation (ie, SSFR < 0.7 mL/min).Results: The baseline prevalence of hyposalivation was 27.8% (85/306) among men and 47.3% (139/294) among women. During a mean (standard deviation) follow-up period of 104 (27) months, 80 deaths occurred: 60 (75.0%) deaths among men and 20 (25.0%) deaths among women. After adjusting for the number of remaining teeth, smoking status, exercise, hypoalbuminemia, diabetes and cardiovascular disease, hyposalivation at baseline was significantly associated with all-cause mortality among men (adjusted hazard ratio, 1.71; 95% confidence interval, 1.01-2.89). In contrast, no association between SSFR and all-cause mortality existed among women.Conclusion: Hyposalivation could be a marker for all-cause mortality among older community-dwelling Japanese men. Future studies investigating the association between SSFR and cause-specific mortality are warranted.