Effective connectivity within the distributed cortical network for face perception
Effective connectivity within the distributed cortical network for face perception
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DOI：
10.1093/cercor/bhl148
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发表时间：
2007-10-01
期刊：
影响因子：
3.7
通讯作者：
Ishai, Alumit
中科院分区：
文献类型：
--
作者：
Fairhall, Scott L.;Ishai, Alumit
人脸感知在人类大脑的一个分布式皮质网络中引发激活。该网络包括视觉（“核心”）区域，以及边缘和前额叶（“扩展”）区域，它们分别处理不变的面部特征和面部的可变方面。我们使用功能磁共振成像和动态因果模型来研究核心系统和扩展系统之间和内部的有效连接和功能组织。我们预测，在观看人脸时，核心和扩展系统之间的连接是腹侧的，而不是背侧的，并测试了价和名气是否会改变网络内的功能耦合。我们发现，核心系统以一种主要的前馈方式分层组织，梭状回（FG）对扩展系统施加主导影响。此外，情绪激动的面孔增加了前脑区和杏仁核之间的耦合，而著名的面孔增加了前脑区和眶额皮质之间的耦合。我们的研究结果证明了视觉边缘和视觉前额叶面部反应通路之间功能耦合的内容特异性动态改变。
Face perception elicits activation within a distributed cortical network in the human brain. The network includes visual ("core") regions, as well as limbic and prefrontal ("extended") regions, which process invariant facial features and changeable aspects of faces, respectively. We used functional Magnetic Resonance Imaging and Dynamic Causal Modeling to investigate effective connectivity and functional organization between and within the core and the extended systems. We predicted a ventral rather than dorsal connection between the core and the extended systems during face viewing and tested whether valence and fame would alter functional coupling within the network. We found that the core system is hierarchically organized in a predominantly feed-forward fashion, and that the fusiform gyrus (FG) exerts the dominant influence on the extended system. Moreover, emotional faces increased the coupling between the FG and the amygdala, whereas famous faces increased the coupling between the FG and the orbitofrontal cortex. Our results demonstrate content-specific dynamic alterations in the functional coupling between visual-limbic and visual-prefrontal face-responsive pathways.