The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women
The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women
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DOI：
10.1016/j.psyneuen.2008.08.012
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发表时间：
2009-01-01
影响因子：
3.7
通讯作者：
Fleming, Alison S.
中科院分区：
文献类型：
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作者：
Gonzalez, Andrea;Jenkins, Jennifer M.;Fleming, Alison S.
在儿童和成人中，早期生活逆境都与下丘脑-垂体-肾上腺(HPA)轴功能障碍有关。然而，在成年期，大多数研究都集中在早期逆境对HPA轴应激反应的影响，而不是皮质醇唤醒反应或昼夜皮质醇分布。这项研究的目的是检验早期生活逆境对产后妇女皮质醇唤醒反应(CAR)和皮质醇昼夜变化的累积影响。90名产后2至6个月的妇女完成了两份回顾报告，评估了不利的早期生活经历(虐待和护理的一致性)，18名妇女报告经历了父母丧失和某种形式的童年虐待，36名妇女报告经历了一种类型的早期生活逆境，要么是失去父母，要么是遭受虐待。通过连续两天收集唾液皮质醇来评估HPA轴功能，以测量皮质醇觉醒反应(n=61)和昼夜皮质醇节律(n=90)。报告经历不良早期生活经历的女性与没有报告不良早期生活经历的女性相比，表现出觉醒皮质醇水平更高的趋势(p=0.07)。这些较高的觉醒皮质醇水平在经历早期逆境的组中持续了整个上午，所有组在下午和晚上都表现出典型的日间下降(p
Early life adversity has been associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction in both children and adults. However, in adulthood, most studies have focused on the effects of early adversity on HPA axis stress reactivity rather than the cortisol awakening response or diurnal cortisol profiles. The goat of this study was to examine the cumulative effects of early life adversity on the cortisol awakening response (CAR) and diurnal cortisol profiles in a sample of postpartum women. Ninety women between 2 and 6 months postpartum completed two retrospective reports assessing adverse early life experiences (maltreatment and consistency of care), Eighteen women reported having experienced both parental loss and some form of childhood maltreatment and 36 women reported having experienced one type of early life adversity, either parental loss or maltreatment. HPA axis function was assessed through salivary cortisol collections over two consecutive days for measurement of the cortisol awakening response (n = 61) and diurnal cortisol rhythm (n = 90). Women who reported experiencing adverse early life experiences exhibited a tendency towards higher levels of awakening cortisol compared to women who reported no adverse early life experiences (p =.07). These higher awakening cortisol levels were sustained throughout the morning in the groups who experienced early adversity, with all groups exhibiting the typical diurnal decline in the afternoon and evening (p