Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.)
Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.)
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DOI：
10.1016/j.phymed.2007.02.001
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发表时间：
2007-04-01
期刊：
影响因子：
7.9
通讯作者：
Elstner, Erich
中科院分区：
文献类型：
--
作者：
Breyer, Anja;Elstner, Matthias;Elstner, Erich
海马 HT22 细胞谷氨酸诱导的细胞死亡是由于谷胱甘肽水平耗尽和细胞内活性氧增加导致的神经元疾病的模型系统。贯叶金丝桃 (HPE) 的标准化提取物含有以抗氧化特性而闻名的黄酮类化合物。在上述模型中，报告了 0.05% HPE 浓度下通过减弱钙通量和细胞能量状态而产生的细胞保护作用。 (c) 2007 年爱思唯尔有限公司。版权所有。
Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported. (c) 2007 Elsevier GmbH. All rights reserved.