Effects of weekly LED therapy at 625 nm on the treatment of chronic lower ulcers
Effects of weekly LED therapy at 625 nm on the treatment of chronic lower ulcers
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DOI：
10.1007/s10103-014-1666-5
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发表时间：
2015-01-01
影响因子：
2.1
通讯作者：
Lupiano Dias, Ivan Frederico
中科院分区：
文献类型：
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作者：
Cardoso Martins Siqueira, Claudia Patricia;Ramos, Solange de Paula;Lupiano Dias, Ivan Frederico
本研究的目的是评估LED疗法与压迫疗法相结合治疗慢性静脉性小腿溃疡(CVU)的效果。这项研究包括有资格接受Unna靴式治疗的CVU患者(n=17，8名男性)。溃疡患者每周接受LED治疗(625 nm，4J/cm(2))和Unna靴子(LED溃疡，n=14)或安慰剂治疗和Unna‘s靴子(对照溃疡，n=14)治疗。记录30周内溃疡的总表面积、相对溃疡面积和愈合率。收集溃疡渗出液，测定局部肿瘤坏死因子-α(TNF-α)水平。在整个研究过程中，LED和对照组溃疡的总面积没有显著差异(P&gT；0.05，Mann-Whitney U检验)。然而，相对面积显示对照组在19周后仍有6个顽固性溃疡(n=6)，P<；0.05，Mann-Whitney U检验。LED组(15周)和对照组(19.5周)的中位愈合率(风险比0.89，可信区间95%：0.40~1.98)无明显差异。两组患者的肿瘤坏死因子-α水平无差异(P>；0.05，Mann-Whitney U检验)。结果表明，LED组在19周后未观察到顽固性溃疡，因此LED治疗提高了Unna‘s靴子的效果。然而，LED治疗并没有改变局部的肿瘤坏死因子-α的分泌，也没有加速伤口的愈合。
The aim of this study was to evaluate the effects of LED therapy associated with compression therapy on chronic venous leg ulcers (CVUs). The study included CVU patients (n = 17, eight men) who were eligible for Unna's boot treatment. Ulcers were treated on a weekly basis with either LED therapy (625 nm, 4 J/cm(2)) and an Unna's boot (LED ulcers, n = 14) or a placebo treatment and an Unna's boot (control ulcers, n = 14). The total surface area of the ulcers, the relative ulcer area, and the healing rate were recorded over a period of 30 weeks. Ulcer exudates were collected for determination of local tumor necrosis factor alpha (TNF-alpha) levels. The total area was not significantly different between the LED and control ulcers (P > 0.05, Mann-Whitney U test) throughout the study. However, the relative area indicated that non-healing treatment resistant ulcers (n = 6) persisted in the control group after 19 weeks (P < 0.05, Mann-Whitney U Test). No differences in median healing rate were observed (hazard ratio 0.89, CI 95 %: 0.40-1.98) between LED (15 weeks) and control ulcers (19.5 weeks). No differences in TNF-alpha levels were detected (P > 0.05, Mann-Whitney U test). The results suggest that LED therapy improved the effectiveness of the Unna's boot since no refractory ulcer was observed in the LED group after 19 weeks. However, LED therapy did not alter the local secretion of TNF-alpha nor accelerate wound healing.