Creola bodies in infancy with respiratory syncytial virus bronchiolitis predict the development of asthma.
Creola bodies in infancy with respiratory syncytial virus bronchiolitis predict the development of asthma.
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患有呼吸道合胞病毒细支气管炎的婴儿期克里奥拉小体可预测哮喘的发生。
DOI：
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发表时间：
2010
影响因子：
6.8
通讯作者：
S. Yoshihara
中科院分区：
文献类型：
--
作者：
Yumi Yamada;S. Yoshihara
背景
痰液中的克理奥拉小体（CrB）是呼吸道上皮损伤的指标，特别出现在支气管哮喘中。我们研究了呼吸道合胞病毒（RSV）毛细支气管炎导致哮喘发展的婴儿中CrB的存在及其临床意义。
方法
从33名患有急性RSV细支气管炎的婴儿中收集了抽吸的痰液样本。然后检查样本是否存在（或不存在）CrB，并将其分为RSV-CrB组和RSV-非CrB组。比较两组患者痰液中嗜酸性粒细胞阳离子蛋白（ECP）和中性粒细胞弹性蛋白酶（NE）的浓度。在出院后2年和5年收集喘息和哮喘史。
结果
在33名受试者中有23名（69.7%）检测到CrB。RSV-CrB组与RSV-non-CrB组之间ECP和NE浓度无显著差异。在RSV细支气管炎中检测到的CrB与复发性喘息和哮喘的发生之间观察到显著相关性（2年后：相对风险[RR]，3.09; p = 0.002; 5年后：RR 7.00; p = 0.019）。
结论
这些结果表明，在RSV毛细支气管炎的婴儿痰中存在高比率的CrB，并且值得注意的是，CrB与复发性喘息和哮喘的进展相关。
BACKGROUND
Creola bodies (CrBs) in the sputum are an indicator of respiratory epithelial damage and appear specifically in bronchial asthma. We studied the presence and clinical significance of CrBs in infants with respiratory syncytial virus (RSV) bronchiolitis contributing to the development of asthma.
METHODS
Aspirated sputum samples were collected from 33 infants admitted with acute RSV bronchiolitis. The samples were then examined for the presence (or absence) of CrBs and classified into the RSV-CrB group and RSV-non-CrB group. Eosinophil cationic protein (ECP) and neutrophil elastase (NE) concentrations in the sputum were compared between the two groups. History of wheeze and asthma was collected at 2 years and 5 years after their discharge from hospital.
RESULTS
CrBs were detected in 23 of the 33 subjects (69.7%). No significant difference in the ECP and the NE concentration were observed between the RSV-CrB group and RSV-non-CrB group. A significant relationship was observed between CrBs detected with RSV bronchiolitis and the development of recurrent wheezing and asthma (after 2 years: relative risk [RR], 3.09; p = 0.002; after 5 years: RR 7.00; p = 0.019).
CONCLUSIONS
These findings suggest that a high rate of CrBs in the sputum is present in infants with RSV bronchiolitis, and notably the CrBs are associated with the progression to recurrent wheezing and asthma.
DOI：
10.1152/ajplung.2001.280.1.l69
发表时间：
2001-01-01
影响因子：
4.9
作者：
Suliman, HB;Ryan, LK;Folz, RJ
通讯作者：
Folz, RJ
DOI：
10.1165/rcmb.2008-0330oc
发表时间：
2009-09-01
影响因子：
6.4
作者：
Hosakote, Yashoda M.;Liu, Tianshuang;Casola, Antonella
通讯作者：
Casola, Antonella