AUTOCATALYTIC ALKYLATION OF THE CYTOCHROME-P-450 PROSTHETIC HEME GROUP BY 1-AMINOBENZOTRIAZOLE - ISOLATION OF AN NN-BRIDGED BENZENE-PROTOPORPHYRIN IX ADDUCT
AUTOCATALYTIC ALKYLATION OF THE CYTOCHROME-P-450 PROSTHETIC HEME GROUP BY 1-AMINOBENZOTRIAZOLE - ISOLATION OF AN NN-BRIDGED BENZENE-PROTOPORPHYRIN IX ADDUCT
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DOI：
10.1042/bj1950761
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发表时间：
1981-01-01
影响因子：
4.1
通讯作者：
MATHEWS, JM
中科院分区：
文献类型：
--
作者：
DEMONTELLANO, PRO;MATHEWS, JM
在1-氨基苯并三唑的催化处理过程中，肝细胞色素P-450的破坏伴随着微粒体血红素的等量损失，但不伴随细胞色素b5的损失或脂质过氧化的刺激。一种异常的卟啉，暂时确定为NN-桥连的苯炔-原卟啉IX加合物，似乎是通过添加催化产生的苯炔到假体血红素形成的。
Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or stimulation of lipid peroxidation. An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyrin IX adduct, appears to be formed by the addition of catalytically generated benzyne to prosthetic haem.