Effects of Prediabetes Mellitus Alone or Plus Hypertension on Subsequent Occurrence of Cardiovascular Disease and Diabetes Mellitus Longitudinal Study
Effects of Prediabetes Mellitus Alone or Plus Hypertension on Subsequent Occurrence of Cardiovascular Disease and Diabetes Mellitus Longitudinal Study
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单独糖尿病前期或合并高血压对随后发生心血管疾病和糖尿病的影响：纵向研究
DOI：
10.1161/hypertensionaha.114.04632
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发表时间：
2015-03-01
期刊：
影响因子：
8.3
通讯作者：
Tian, Jingyan
中科院分区：
文献类型：
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作者：
Qiu, Miaoyan;Shen, Weili;Tian, Jingyan
糖尿病前期是否单独或合并其他疾病意味着更高的心血管疾病（CVD）风险仍有争议。本研究旨在探讨糖尿病前期与心血管疾病和糖尿病之间的关系，并探讨糖尿病前期单独或与其他综合征（如高血压）合并是否会显著增加心血管疾病的风险。这项基于人群的纵向研究在2002年至2014年期间对来自中国南方上海的1609名居民进行了研究。基线时有CVD病史的参与者被排除在分析之外。多元对数二项回归模型用于调整可能的共存因素。随访期间CVD的发生率为10.1%。在调整年龄、性别和其他因素后，未观察到糖尿病前期与CVD之间的关联。当分层因素中加入高血压时，糖尿病前期和高血压合并组校正的CVD危险性显著升高（比值比2.41; 95%可信区间1.25-4.64），糖尿病和高血压并存组CVD危险性显著升高，是对照组的3.43倍。经多变量校正后，处于糖尿病前期范围内的血糖水平与糖尿病风险升高显著相关，但仅当其与其他疾病（如高血压）并发时，才会显著增加CVD风险。
Whether prediabetes mellitus alone or combined with other disorders means a higher risk for cardiovascular disease (CVD) is still controversial. This study aimed to investigate the association between prediabetes mellitus and CVD and diabetes mellitus and to explore whether prediabetes mellitus alone or combined with other syndromes, such as hypertension, could promote CVD risks significantly. This longitudinal population-based study of 1609 residents from Shanghai in Southern China was conducted between 2002 and 2014. Participants with a history of CVD at baseline were excluded from analysis. Multivariate log-binomial regression models were used to adjust possible coexisting factors. Incidence of CVD during follow-up was 10.1%. After adjusting for age, sex, and other factors, the association between prediabetes mellitus and CVD was not observed. When hypertension was incorporated in stratifying factors, adjusted CVD risk was elevated significantly (odds ratio, 2.41; 95% confidence interval, 1.25–4.64) in prediabetes mellitus and hypertension combined group, and coexistence of diabetes mellitus and hypertension made CVD risk highly significantly increased, reaching 3.43-fold higher than the reference group. Blood glucose level within prediabetic range is significantly associated with elevated risks for diabetes mellitus after multivariable adjustment, but only when it is concurrent with other disorders, such as hypertension, it will significantly increase CVD risk.