Quantitation of arterial spin labeling MRI labeling efficiency in high cervical velocity conditions using phase contrast angiography
Quantitation of arterial spin labeling MRI labeling efficiency in high cervical velocity conditions using phase contrast angiography
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使用相差血管造影术定量高颈椎速度条件下的动脉自旋标记 MRI 标记效率
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
M. Donahue
中科院分区：
文献类型：
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作者：
Meher R. Juttukonda;L. Jordan;Melissa C. Gindville;S. Pruthi;M. Donahue
本研究的目的是使用相位对比血管造影（PCA）MRI测量供应大脑的四条主要血管的流速，并使用这些测量值来估计流速可变的患者颈部血管中流行的脑血流（CBF）加权动脉自旋标记（ASL）方法的标记效率。对对照组（n=7）和已知血流速度升高的镰状细胞病（SCD）患者（n=19）进行ASL和PCA扫描。使用PCA计算颈内动脉和椎动脉的平均血流速度。通过要求PCA和ASL之间的CBF相同来计算ASL标记效率。结果显示，SCD患者的ASL标记效率显著低于对照组（p<0.05），当使用不控制流速的标记效率时，导致ASL对CBF的低估;提出了解决这一基本限制的方法。
The objective of this study is to measure flow velocities in the four major vessels supplying the brain using phase contrast angiography (PCA) MRI and to use these measurements to estimate labeling efficiency in the popular cerebral blood flow (CBF)-weighted arterial spin labeling (ASL) approach in patient cervical vessels with variable flow velocity. ASL and PCA scans were performed on controls (n=7), and patients with sickle cell disease (SCD) with known, elevated flow velocity (n=19). Mean blood flow velocities were computed for the internal carotid and vertebral arteries using PCA. ASL labeling efficiencies were calculated by requiring that the CBF be identical between PCA and ASL. The results showed that ASL labeling efficiencies in patients with SCD are significantly lower (p<;0.05) than in controls, causing an underestimation of CBF from ASL when using labeling efficiencies that do not control for flow velocity; solutions for this fundamental limitation are proposed.