EXPERIMENTAL GLYCEROL MYOPATHY - A HISTOLOGICAL STUDY
EXPERIMENTAL GLYCEROL MYOPATHY - A HISTOLOGICAL STUDY
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DOI：
10.1007/bf00308923
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发表时间：
1990-01-01
影响因子：
12.7
通讯作者：
IWASA, M
中科院分区：
文献类型：
--
作者：
KAWAI, H;NISHINO, H;IWASA, M
本文研究了肌注甘油对兔肌纤维的组织病理学改变。注射1毫升50%(v/v)甘油15分钟后，可见肌纤维过度收缩，质膜断裂，镧侵入肌浆。注射后12~24 h出现更广泛的病理改变，包括：纤维大小变化；肌纤维变性和坏死；光镜下纤维过度收缩；电子显微镜下质膜破裂；空泡状改变；肌原纤维过度收缩，Z带选择性丢失。注射甘油后7~14天，可见广泛的再生改变。这些退行性改变与Duchenne肌营养不良症的肌肉中的变化相似，提示这两种情况下可能存在相似的机制，因此实验性甘油肌病可能是Duchenne肌营养不良症的一个很好的病理生理研究模型。
Histopathological changes induced by the intramuscular injection of glycerol were studied in the muscle fibers of rabbits. Fifteen minutes after the injection of 1 ml of 50% (v/v) glycerol, hypercontraction of fibers, disruption of the plasma membrane, and invasion of lanthanum into the sarcoplasm were observed. Between 12 and 24 h after the injection, more extensive pathological changes were seen which included: variation in fiber size; degeneration and necrosis of muscle fibers; hypercontraction of fibers by light microscopy; disruption of the plasma membrane by electron microscopy; vacuolar changes; hypercontraction of myofibrils, and selective loss of Z-bands. Between 7 and 14 days after glycerol injection, extensive regenerative changes were seen. The degenerative changes were similar to those seen in muscle in Duchenne muscular dystrophy, suggesting that a similar mechanism may be involved in the two conditions so that experimental glycerol myopathy could be a good model for pathophysiological studies on Duchenne muscular dystrophy.