From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.
From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.
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DOI：
10.1016/j.jid.2021.05.024
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
COVID Human Genetic Effort
中科院分区：
文献类型：
--
作者：
Arkin LM;Moon JJ;Tran JM;Asgari S;O'Farrelly C;Casanova JL;Cowen EW;Mays JW;Singh AM;Drolet BA;COVID Human Genetic Effort
尽管报告了数千例与大流行相关的冻疮患者，但血清转换率和PCR阳性率较低，无法确定与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的因果关系。未感染儿童的败血症与IFN-1免疫力过度的单基因疾病有关，而严重的COVID-19肺炎可能由IFN-1不足引起。此外，SARS-CoV-2刺突蛋白和强有力的IFN-1反应出现在大流行相关性冻疮患者的皮肤中，表明对SARS-CoV-2的过度先天免疫皮肤反应。了解这一现象的病理生理学可能会阐明宿主对SARS-CoV-2产生弹性免疫反应的机制，并可能产生相关的治疗靶点。
Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.
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危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
9.8
作者：
Rice, Gillian;Newman, William G.;Crow, Yanick J.
通讯作者：
Crow, Yanick J.
影响因子：
10.9
作者：
Guenther, Claudia;Berndt, Nicole;Lee-Kirsch, Min Ae
通讯作者：
Lee-Kirsch, Min Ae
影响因子：
13.8
作者：
Freeman, Esther E.;McMahon, Devon E.;Fox, Lindy P.
通讯作者：
Fox, Lindy P.
影响因子：
3.3
作者：
Magro CM;Mulvey JJ;Laurence J;Seshan S;Crowson AN;Dannenberg AJ;Salvatore S;Harp J;Nuovo GJ
通讯作者：
Nuovo GJ