Nuclear genomic signals of the "microturbellarian" roots of platyhelminth evolutionary innovation
Nuclear genomic signals of the "microturbellarian" roots of platyhelminth evolutionary innovation
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DOI：
10.7554/elife.05503
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发表时间：
2015-03-12
期刊：
影响因子：
7.7
通讯作者：
Giribet, Gonzalo
中科院分区：
文献类型：
--
作者：
Laumer, Christopher E.;Hejnol, Andreas;Giribet, Gonzalo
扁形虫是最多样化的无脊椎动物门之一，是主要两侧分支螺旋体中最具生物医学意义的分支，但迄今为止，这一群体内部的深层进化关系仅使用单一位点（rRNA操纵子）进行了研究，许多关键分支的起源尚不清楚。在这里，使用一个调查的基因组和转录组代表所有自由生活的扁形虫订单，我们提供的决议的基础上，数以百计的核蛋白编码基因的扁形动物的相互关系，探索系统发育信号，通过串联以及最近开发的共识方法。这些分析有力地支持了扁形虫发生的现代假设，该假设强调了经常被忽视的“微涡虫”群体在理解扁形动物内部主要进化转变方面的首要地位：也许最值得注意的是，我们提出了一个新的方案之间的相互关系自由生活和脊椎动物寄生扁形虫，提供了新的机会来阐明这些标志性无脊椎动物寄生的起源和生物学后果。
Flatworms number among the most diverse invertebrate phyla, and represent the most biomedically significant branch of the major bilaterian clade Spiralia, but to date, deep evolutionary relationships within this group have been studied using only a single locus (the rRNA operon), leaving the origins of many key clades unclear. Here, using a survey of genomes and transcriptomes representing all free-living flatworm orders, we provide resolution of platyhelminth interrelationships based on hundreds of nuclear protein-coding genes, exploring phylogenetic signal through concatenation as well as recently developed consensus approaches. These analyses robustly support a modern hypothesis of flatworm phylogeny, one which emphasizes the primacy of the often-overlooked "microturbellarian" groups in understanding the major evolutionary transitions within Platyhelminthes: perhaps most notably, we propose a novel scenario for the interrelationships between free-living and vertebrate-parasitic flatworms, providing new opportunities to shed light on the origins and biological consequences of parasitism in these iconic invertebrates.