Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over
Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over
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DOI：
10.1017/s0007114599000380
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发表时间：
1999-03-01
影响因子：
3.6
通讯作者：
Finch, S
中科院分区：
文献类型：
--
作者：
Bates, CJ;Pentieva, KD;Finch, S
磷酸吡哆醛和吡哆酸的浓度测定空腹血浆样本的英国男性和女性年龄在65岁及以上，参加了1994年至1995年的全国饮食和营养调查，选择代表英国大陆的人口。在这一人群中，磷酸吡哆醛的浓度下降，而吡哆酸上升，随着年龄的增长和虚弱;然而，这两个状态指标强烈和直接（正系数）与维生素B-6摄入量的估计。在模型中加入食物能量和蛋白质摄入量几乎没有影响。48%的社区参与者和75%的机构参与者的血浆磷酸吡哆醛浓度低于其他研究中认为正常的范围。在单变量回归模型中，血浆磷酸吡哆醛浓度与血浆同型半胱氨酸浓度呈负相关，这与维生素B-6状态可能影响血浆同型半胱氨酸水平，从而影响血管疾病风险的假设一致。然而，在包括年龄、性别、住所和生化状态指数（包括叶酸和维生素B-12）的多元回归模型中，这种关系部分减弱。有证据表明，血浆磷酸吡哆醛对与炎症和急性期反应相关的代谢状况敏感，血浆吡哆酸对肾功能敏感。因此，除非考虑到这些混杂因素，否则这两个指数都不是老年人维生素B-6状态的理想预测指标。由于维生素B-6缺乏可能对健康产生影响，例如对老年人的免疫功能、认知和基本中间代谢途径产生影响，因此需要将其作为一个可能的公共卫生问题进行调查。
Concentrations of pyridoxal phosphate and pyridoxic acid were measured in fasting plasma samples from British men and women aged 65 years and over, participating in a National Diet and Nutrition Survey during 1994-5, selected to be representative of the population of mainland Britain. In this population, the concentration of pyridoxal phosphate declined, whereas pyridoxic acid rose, with increasing age and frailty; however, both status indicators were strongly and directly (with a positive coefficient) correlated with estimates of vitamin B-6 intake. This was little affected by the inclusion of food energy and protein intakes in the model. Forty-eight percent of the participants living in the community and 75 % of those living in institutions had plasma pyridoxal phosphate concentrations below a range considered normal from other studies. In a univariate regression model, plasma pyridoxal phosphate concentrations were inversely correlated with plasma homocysteine concentrations, consistent with the hypothesis that vitamin B-6 status may influence plasma homocysteine levels, and hence vascular disease risk. However, this relationship was partly attenuated in a multiple regression model including age, sex, domicile and biochemical status indices, including those of folate and vitamin B-12. There was evidence that plasma pyridoxal phosphate was sensitive to metabolic conditions associated with inflammation and the acute-phase reaction, and that plasma pyridoxic acid was sensitive to renal function. Thus, neither index is an ideal predictor of vitamin B-6 status in older people, unless these confounding factors are allowed for. Since poor vitamin B-6 status may have health implications, e.g. for immune function, cognition, and for essential intermediary metabolic pathways in older people, it needs to be investigated as a possible public health problem.