INTRINSIC SIGNAL CHANGES ACCOMPANYING SENSORY STIMULATION - FUNCTIONAL BRAIN MAPPING WITH MAGNETIC-RESONANCE-IMAGING
INTRINSIC SIGNAL CHANGES ACCOMPANYING SENSORY STIMULATION - FUNCTIONAL BRAIN MAPPING WITH MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1073/pnas.89.13.5951
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发表时间：
1992-07-01
影响因子：
11.1
通讯作者：
UGURBIL, K
中科院分区：
文献类型：
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作者：
OGAWA, S;TANK, DW;UGURBIL, K
我们报告说，视觉刺激产生一个很容易检测到的（5-20%）瞬态增加的水质子磁共振信号的强度在人类初级视觉皮层梯度回波图像在4-T磁场强度。观察到的变化主要发生在含有灰质的区域，可用于产生高空间分辨率的人类功能脑图。将图像采集回波时间从40毫秒减少到8毫秒降低了分数信号变化的幅度，这表明它是由表观横向弛豫时间T2* 的变化产生的。这些内在信号变化的幅度、符号和回波时间依赖性与神经激活增加局部脑血流量并伴随增加静脉血氧合的想法一致。
We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.