Evidence that the attentional set shifting test in rats can be applied in repeated testing paradigms
Evidence that the attentional set shifting test in rats can be applied in repeated testing paradigms
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大鼠注意力转移测试可应用于重复测试范例的证据
DOI：
10.1177/0269881114531663
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发表时间：
2014
影响因子：
4.1
通讯作者：
S. Gartside
中科院分区：
文献类型：
--
作者：
J. Wallace;HM Marston;R. Mcquade;S. Gartside
注意集转移任务（注意集转移任务）可用于评估执行功能的各个方面，包括反转学习和集转移。它经常被用于受试者之间的实验设计：然而，受试者内设计的明显优势（减少方差、动物数量和成本）意味着对受试者内设计的适应性进行调查是有必要的。试验1（训练后24 h）、试验2（训练后24 h）、试验3（训练后7 d）共进行3次试验。在所有三个测试日，动物在七个任务阶段表现出预期的表现模式，有证据表明正常的反转学习（当规则被反转时，对标准的试验显著增加）和完整的集合形成（对标准的试验明显多于对内维转移的试验）。在测试1和测试3之间，完成任务所需的总试验次数略有减少，但这并不特定于任务的任何阶段。重复测试后挖掘延迟时间减少，提示联想学习有一定的促进作用。总之，啮齿动物皮肤试验适合于受试者内部设计的纵向研究，增加了该测试的效用和转化价值，减少了研究中所需的动物数量。
The attentional set shifting task (ASST) can be used to assess aspects of executive function, including reversal learning and set shifting. It has frequently been employed in between-subjects experimental designs: however, the clear advantages of within-subjects designs (reduction in variance, animal numbers, and cost) mean that investigation of the suitability of the ASST for within subjects designs is warranted. Rats were tested three times: test 1 (24 h after training), test 2 (24 h later), and test 3 (seven days later). On all three test days, animals showed the expected pattern of performance across the seven task stages with evidence of normal reversal learning (significant increase in trials to criterion when the rule was reversed) and intact set formation (significantly more trials to criterion for an extradimensional shift than for an intradimensional shift). There was a small decrease in total trials required to complete the task between test 1 and test 3 but this was not specific to any stage of the task. Latency to dig decreased on repeated testing suggesting some facilitation of associative learning. In conclusion, the rodent ASST is suitable for within-subject design longitudinal studies, increasing the utility and the translational value of this test and reducing numbers of animals needed in studies.
影响因子：
3.7
作者：
Glickstein, SB;DeSteno, DA;Schmauss, C
通讯作者：
Schmauss, C