Assessment of the effects of a fluoride dentifrice and GC Tooth Mousse on early caries lesions in primary anterior teeth using quantitative light-induced fluorescence: a randomised clinical trial
Assessment of the effects of a fluoride dentifrice and GC Tooth Mousse on early caries lesions in primary anterior teeth using quantitative light-induced fluorescence: a randomised clinical trial
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DOI：
10.1007/s40368-019-00451-7
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发表时间：
2020-02-01
影响因子：
2.2
通讯作者：
Al-Khateeb, S. N.
中科院分区：
文献类型：
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作者：
Al-Batayneh, O. B.;Bani Hmood, E. I.;Al-Khateeb, S. N.
目的比较单独使用含氟牙膏与局部使用CPP-ACP乳膏作为牙膏的效果，以及两种药物联合使用（氟化物牙膏后使用CPP-ACP乳膏）对儿童初级前牙早期龋损（ECL）的影响，为期6个月。方法采用单盲随机临床试验方法，将114例4 ~ 5岁的高龋风险儿童（n = 114）分为三组，每组均有至少一颗乳牙前牙ECL （ICDAS 2）。受试者每天使用两次不同的药物：含氟牙膏（500 ppm F, n = 42）， CPP-ACP霜（10% w/v, n = 35），含氟牙膏后再使用CPP-ACP霜（n = 37）。使用QLF跟踪病变的变化，将基线情况与治疗3个月和6个月进行比较。结果QLF变化与矿物质增加（增加F/荧光，病变面积）一致（基线与3个月或6个月，p 0.05）。结论单独外用CPP-ACP乳膏与含氟牙膏效果相近；然而，这两种药物的联合使用并没有比单独使用任何一种药物带来额外的好处。
Purpose To compare the effects of a fluoride dentifrice alone, versus a topical CPP-ACP creme used as a dentifrice, versus the combination of both agents (fluoride dentifrice followed by CPP-ACP creme) on early caries lesions (ECL) in primary anterior teeth of children over a 6-month period. Methods In this single blinded randomised clinical trial, children (n = 114, aged 4-5 years) with high caries risk and who had at least one ECL (ICDAS 2) on their primary anterior teeth were allocated to three groups. Subjects used different agents twice daily: fluoride dentifrice (500 ppm F, n = 42), CPP-ACP creme (10% w/v, n = 35), and the fluoride dentifrice followed by CPP-ACP creme (n = 37). Changes in lesions were tracked using QLF, comparing the baseline situation to 3 and 6 months of treatment. Results QLF changes consistent with mineral gain ( increment F/fluorescence, lesion area) occurred in all three groups (baseline versus 3 months or 6 months, p 0.05). Conclusion The topical CPP-ACP creme used alone gave effects similar to the fluoride dentifrice; however, the combination of the two did not give additive benefits over either agent used in isolation.