Proximal tubular adenomas of kidney with so‐called oncocytic features. A clinicopathologic study of 13 cases of a rarely reported neoplasm
Proximal tubular adenomas of kidney with so‐called oncocytic features. A clinicopathologic study of 13 cases of a rarely reported neoplasm
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具有所谓嗜酸细胞特征的肾近端管状腺瘤的 13 例罕见肿瘤的临床病理学研究。
作者：
Michael J. Klein;Q. Valensi
1974年7月至1975年1月在大学医院观察到4例肾“嗜酸细胞瘤”。回顾了自1952年以来被归类为癌的所有肾细胞肿瘤，以确定这组肿瘤是否代表了最近发病率的增加，或者其他肾“嗜酸细胞瘤”是否在过去未被认识。对194例癌的23年回顾产生了另外9例“嗜酸细胞瘤”。在1964年之前没有发现过，而仅在1973-1975年期间就发现了近一半。虽然似乎有些肾脏的“嗜酸细胞瘤”在过去没有被认识到，但也很明显，它们最近的发病率增加在流行病学上具有重要意义。比较肾嗜酸细胞瘤和肾细胞癌的形态、临床表现和生物学行为。从这种比较中得出的证据允许得出这样的结论，即这些肿瘤起源于近端肾小管上皮，是良性临床病理实体，因此应称为具有所谓“嗜酸性”特征的近端肾小管腺瘤。
Four renal “oncocytomas” were observed between July 1974 and January 1975 at University Hospital. A review of all renal cell neoplasms previously classified as carcinomas since 1952 was conducted to determine whether this cluster of tumors represented a recent increase in incidence or whether other renal “oncocytomas” had gone unrecognized in the past. The 23‐year review of 194 carcinomas yielded an additional nine “oncocytomas.” None had appeared prior to 1964, whereas almost half were found in the 1973–1975 interval alone. While it appears that some “oncocytomas” of the kidney have gone unrecognized in the past, it is also evident that their recent increased incidence is epidemiologically significant. Renal “oncocytomas” and renal cell carcinomas are compared with respect to morphology, clinical presentation, and biologic behavior. Evidence derived from this comparison permits the conclusion that these neoplasms originate from proximal tubular epithelium, are benign clinicopathologic entities, and henceforth should be called proximal tubular adenomas with so‐called “oncocytic” features.