Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients.
Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients.
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DOI：
10.1159/000381800
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发表时间：
2015-05
影响因子：
2.3
通讯作者：
Ikeda M
中科院分区：
文献类型：
--
作者：
Hashimoto M;Yatabe Y;Ishikawa T;Fukuhara R;Kaneda K;Honda K;Yuki S;Ogawa Y;Imamura T;Kazui H;Kamimura N;Shinagawa S;Mizukami K;Mori E;Ikeda M
痴呆的行为和心理症状（Behavioral and Psychological Symptoms of Dementia，BPSD）是痴呆的常见临床表现。虽然大多数痴呆患者在疾病过程中表现出一定的BPSD，但BPSD与痴呆阶段的关联仍不清楚。本研究的目的是评估痴呆严重程度对路易体痴呆（DLB）和阿尔茨海默病（AD）患者BPSD表达的影响。从日本8家痴呆症诊所招募了97例DLB患者和393例AD患者。采用神经精神量表（NPI）评定BPSD。在每种类型的痴呆症中，评估BPSD和痴呆症分期（由临床痴呆症评分（CDR）分类）之间的关系。在DLB组中，不同CDR分期的NPI总分无显著差异。另一方面，在AD组中，NPI总分随着痴呆阶段的增加而显著增加。BPSD表达与痴呆分期的关系因痴呆类型而异。BPSD和痴呆阶段相关的AD受试者，其中精神症状随着疾病的进展而增加，但在DLB受试者。
Behavioral and psychological symptoms of dementia (BPSD) are common in the clinical manifestation of dementia. Although most patients with dementia exhibit some BPSD during the course of the illness, the association of BPSD with the stage of dementia remains unclear. It was the aim of this study to evaluate the impact of severity of dementia on the expression of BPSD in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Ninety-seven patients with DLB and 393 patients with AD were recruited from 8 dementia clinics across Japan. BPSD were assessed by the Neuropsychiatric Inventory (NPI). A relationship between BPSD and dementia stage classified by the Clinical Dementia Rating (CDR) in each type of dementia was assessed. No significant difference was seen in NPI total score across CDR staging in the DLB group. On the other hand, the NPI total score significantly increased with dementia stage in the AD group. The relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects.